ArticleCancer immunology research2021
Activating Mucosal-Associated Invariant T Cells Induces a Broad Antitumor Response.
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Article in Cancer immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
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Who cites it
43 citing papers in PubMed, 57 citations in OpenAlex.
- Review
- Unconventional T cells in urological cancers: catch them if you can.Nature reviews. Urology · 2026Review
- 4-1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions.Immunology and cell biology · 2026Article
- Commentary: Yin and Yang of MAITs in HCC: balancing type 1 vs. type 17 signaling.Cellular & molecular immunology · 2026Article
- Article
- Brain-Resident MAIT Cells Infiltrate GL261 Tumors, and Activated MAIT Cell Signatures Are Associated With Improved Outcomes in Glioma.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- ReprogrammingmBio · 2026Article
- Unconventional guardians of the brain: MAIT cells as emerging players in glioblastoma immunity.Frontiers in immunology · 2026Review
- Mucosal-associated invariant T cells recognize a tumor-derived metabolite in the DNA synthesis pathway.Frontiers in immunology · 2026Article
- Navigating the gastric frontier of mucosal immunity againstFrontiers in immunology · 2026Review
- Acetoacetate suppresses colon cancer via an MR1-MAIT axis.bioRxiv : the preprint server for biology · 2025Article
- Mucosal-Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2025Review
- MAIT cells promote cancer progression and regulatory T cell accumulation in bladder tumor microenvironment.Journal for immunotherapy of cancer · 2025Article
- SPP1 + macrophages cause exhaustion of tumor-specific T cells in liver metastases.Nature communications · 2025Article
- Biological and clinical significance of tumour-infiltrating lymphocytes in the era of immunotherapy: a multidimensional approach.Nature reviews. Clinical oncology · 2025Review
- MAIT cells: Conserved watchers on the wall.The Journal of experimental medicine · 2025Review
- Unconventional T cells in anti-cancer immunity.Frontiers in immunology · 2025Review
- Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis.Frontiers in cell and developmental biology · 2025Review
- An unconventional purine connection.The Journal of experimental medicine · 2024Article
- Innate immune cells in tumor microenvironment: A new frontier in cancer immunotherapy.iScience · 2024Review
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Benjamin RufGastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-2501-4471
Vanessa V CataniaGastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-0936-994X
Simon WabitschGastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-0915-4466
Chi MaGastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-4171-0813
Laurence P DiggsGastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Qianfei ZhangGastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Bernd HeinrichGastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-0033-2462
Varun SubramanyamGastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Linda L CuiGastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Marie PouzollesPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-1808-820X
Christine N EvansGenome Modification Core, Frederick National Lab for Cancer Research, National Cancer Institute, Frederick, Maryland.
Raj ChariGenome Modification Core, Frederick National Lab for Cancer Research, National Cancer Institute, Frederick, Maryland.ORCID 0000-0002-2216-313X
Shunsuke SakaiT Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Sangmi OhTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.ORCID 0000-0003-0895-1110
Clifton E BarryTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.ORCID 0000-0002-2927-270X
Daniel L BarberT Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Tim F GretenGastrointestinal Malignancy Section, Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. tim.greten@nih.gov.ORCID 0000-0002-0806-2535
National Cancer Institute · USNational Institute of Allergy and Infectious Diseases · USFrederick National Laboratory for Cancer Research · USNational Institutes of Health · US
Funding
Analysis of myeloid derived suppressor cells in miceZIABC011345 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GRETEN, TIM · 2010 to 2025
$19.5MImmune Regulation in Mycobacterial InfectionsZIAAI001171 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARBER, DANIEL · 2012 to 2025
$16.7MLiver Cancer ProgramZIABC011870 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, XIN WEI · 2019 to 2025
$10.1MIntramural NIH HHS ZIA BC011345
Abstract
Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells that recognize non-peptide antigens including riboflavin derivates. Although
Indexed as
AnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensCell Line, TumorCRISPR-Cas SystemsFemaleHistocompatibility Antigens Class IHumansLectins, C-TypeLymphocyte ActivationMaleMiceMinor Histocompatibility AntigensMucosal-Associated Invariant T CellsNeoplasms5-(2-oxopropylideneamino)-6-d-ribitylaminouracilAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensHistocompatibility Antigens Class ILectins, C-TypeMinor Histocompatibility AntigensMr1 protein, mouseRibitolRiboflavinUracil
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