Evidence map›Paper›PMID 34193433›Full record

ArticleBMJ open respiratory research2021

Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic.

Hana B Ruran, Gary Adamkiewicz, Amparito Cunningham, Carter R Petty, Kimberly F Greco, Sigfus Gunnlaugsson, Natalie Stamatiadis, Gabriella Sierra, Jose Vallarino, Marty Alvarez and 5 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04107701 (Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04107701 completednot on this map

Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD

TypeobservationalSponsorBoston Children's HospitalRan2019 to 2025Enrolled165ConditionsBronchopulmonary Dysplasia, Chronic Lung Disease of Newborn, Environmental Exposure
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Associations of Early Life Ambient PMPediatric pulmonology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Hana B RuranBoston Children's Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USA.
Gary AdamkiewiczDepartment of Environmental Health, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Amparito CunninghamBoston Children's Hospital Division of Immunology, Boston, Massachusetts, USA.
Carter R PettyBoston Children's Hospital, Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Boston, Massachusetts, USA.
Kimberly F GrecoBoston Children's Hospital, Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Boston, Massachusetts, USA.
Sigfus GunnlaugssonBoston Children's Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USA.
Natalie StamatiadisBoston Children's Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USA.
Gabriella SierraBoston Children's Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USA.
Jose VallarinoDepartment of Environmental Health, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Marty AlvarezDepartment of Environmental Health, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Lystra P HaydenBoston Children's Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USA.
Catherine A SheilsBoston Children's Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USA.
Edie WellerBoston Children's Hospital, Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Boston, Massachusetts, USA.
Wanda PhipatanakulBoston Children's Hospital Division of Immunology, Boston, Massachusetts, USA.ORCID 0000-0001-8639-0473
Jonathan M GaffinBoston Children's Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USA jonathan.gaffin@childrens.harvard.edu.
Boston Children's Hospital · USHarvard University · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Project 3: Cumulative Risk and Geospatial Health Disparities Related to Chemical and Non-Chemical Stressor ExposuresP50MD010428 · NIMHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI LADEN, FRANCINE · 2015 to 2020
$4.0M
Indoor Air Quality and Respiratory Morbidity in School-Aged Children with Bronchopulmonary DysplasiaR01ES030100 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI GAFFIN, JONATHAN MARK · 2019 to 2023
$3.7M
Midcareer Investigator Award: Urban School Allergen Exposures and Childhood AsthmK24AI106822 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2013 to 2022
$1.9M
Genetic Epidemiology of Respiratory Function in Former Preterm ChildrenK23HL136851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HAYDEN, LYSTRA P. · 2018 to 2022
$969k
NHLBI NIH HHS K23 HL136851NIAID NIH HHS K24 AI106822NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES030100NIMHD NIH HHS P50 MD010428
6 · The paper itself

Abstract

introductionAlmost half of all school-age children with bronchopulmonary dysplasia (BPD) have asthma-like symptoms and more suffer from lung function deficits. While air pollution and indoor respiratory irritants are known to affect high-risk populations of children, few studies have objectively evaluated environmental contributions to long-term respiratory morbidity in this population. This study aimed to examine the role of indoor environmental exposures on respiratory morbidity in children with BPD. METHODS AND ANALYSIS: The Air quality, Environment and Respiratory Ouctomes in BPD (AERO-BPD) study is a prospective, single-centre observational study that will enrol a unique cohort of 240 children with BPD and carefully characterise participants and their indoor home environmental exposures. Measures of indoor air quality constituents will assess the relationship of nitrogen dioxide (NO ETHICS AND DISSEMINATION: Study protocol was approved by the Boston Children's Hospital Committee on Clinical Investigation. Dissemination will be in the form of peer-reviewed publications and participant information products. TRIAL REGISTRATION NUMBER: NCT04107701.

Indexed as

Air PollutionBronchopulmonary DysplasiaEnvironmental ExposureParticulate MatterAir Pollution, IndoorAllergensAsthmaChildCohort StudiesCOVID-19FemaleHumansHumidityMaleNitric OxideNitrogen DioxideAllergensNitric OxideNitrogen DioxideParticulate MatterPaediatric Lung Disaese

Identifiers

PMID34193433
PMCPMC8249170
OpenAlexW3175570679

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.