ArticleScience advances2021
Helical springs as a color indicator for determining chirality and enantiomeric excess.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Ring-Opening Metathesis Copolymerization of [7]Helicene-Fused Oxanorbornene and Norbornene: Polymerization Control and Physical Properties.Chemistry, an Asian journal · 2026Article
- Facial Asymmetry in the Helical Grooves of Chiral Helical Polymers to Create 2D Single-Chain Archimedean Spiral Nanostructures.ACS nano · 2025Article
- Visualization of enantiorecognition by excited-state conformation modulation.Nature communications · 2025Article
- Thermal Activation of Asymmetry Amplification Effects in Helical Polymer-Metal Complexes.Angewandte Chemie (International ed. in English) · 2025Article
- Colorimetric Visualization of Chirality: From Molecular Sensors to Hierarchical Extension.Molecules (Basel, Switzerland) · 2025Review
- Determination of Enantiomeric Excess by Optofluidic Microlaser near Exceptional Point.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Synthesis and applications of helical polymers with dynamic and static memories of helicity.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Review
- Control of One-Handed Helicity in Polyacetylenes: Impact of an Extremely Small Amount of Chiral Substituents.Journal of the American Chemical Society · 2023Article
- Diastereomeric multi-chiral pendant groups: Their key role in stimuli-responsive polymeric responses.Chirality · 2023Article
- Full Control of the Chiral Overpass Effect in Helical Polymers: P/M Screw Sense Induction by Remote Chiral Centers After Bypassing the First Chiral Residue.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chirality plays a key role in the physiological system, because molecular functionalities may drastically alter due to a change in chirality. We report herein a unique color indicator with a static helicity memory, which exhibits visible color changes in response to the chirality of chiral amines. A difference of less than 2% in the enantiomeric excess (ee) values causes a change in the absorption that is visible to the naked eyes. This was further quantified by digital photography by converting to RGB values. This system relies on the change in the tunable helical pitch of the π-conjugated polymer backbone in specific solvents and allows rapid on-site monitoring of chirality of nonracemic amines, including drugs, and the simultaneous quantitative determination of their ee values.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.