ArticleScience advances2021
The essential role of recurrent processing for figure-ground perception in mice.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 82 citations in OpenAlex.
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- An inhibitory brainstem pathway reduces visual detection during background motion.Nature communications · 2026Article
- Acute requirement for the hippocampus in putatively conscious vision revealed by a mouse model of blindsight.Current biology : CB · 2026Article
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- Gestalt laws enhance the representation of figures over backgrounds in the visual cortex and influence contrast perception.Scientific reports · 2026Article
- How the visual brain can learn to parse images using a multiscale, incremental grouping process.PLoS computational biology · 2026Article
- Functional bipartite invariance in mouse primary visual cortex receptive fields.Nature neuroscience · 2026Article
- Feature-tuned synaptic inputs to somatostatin interneurons drive context-dependent processing.Neuron · 2026Article
- Functional organization and natural scene responses across mouse visual cortical areas revealed with encoding manifolds.PloS one · 2026Article
- Context-dependent activation of V1 parvalbumin interneurons enhances visual discrimination.PLoS biology · 2025Article
- Orientation-tuned surround-suppression is strongest within perceived 3D surfaces.Journal of vision · 2025Article
- Broadband visual stimuli improve neuronal representation and sensory perception.Nature communications · 2025Article
- Modulatory feedback determines attentional object segmentation in a model of the ventral stream.PloS one · 2025Article
- Border-ownership tuning determines the connectivity between V4 and V1 in the macaque visual system.Nature communications · 2024Article
- The Neural and Computational Architecture of Feedback Dynamics in Mouse Cortex during Stimulus Report.eNeuro · 2024Article
- Oscillations in an artificial neural network convert competing inputs into a temporal code.PLoS computational biology · 2024Article
- Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
The segregation of figures from the background is an important step in visual perception. In primary visual cortex, figures evoke stronger activity than backgrounds during a delayed phase of the neuronal responses, but it is unknown how this figure-ground modulation (FGM) arises and whether it is necessary for perception. Here, we show, using optogenetic silencing in mice, that the delayed V1 response phase is necessary for figure-ground segregation. Neurons in higher visual areas also exhibit FGM and optogenetic silencing of higher areas reduced FGM in V1. In V1, figures elicited higher activity of vasoactive intestinal peptide-expressing (VIP) interneurons than the background, whereas figures suppressed somatostatin-positive interneurons, resulting in an increased activation of pyramidal cells. Optogenetic silencing of VIP neurons reduced FGM in V1, indicating that disinhibitory circuits contribute to FGM. Our results provide insight into how lower and higher areas of the visual cortex interact to shape visual perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.