Evidence map›Paper›PMID 34193016›Full record

ArticleBioengineered2021

Cullin3 aggravates the inflammatory response of periodontal ligament stem cells via regulation of SHH signaling and Nrf2.

Wanhong Chen, Jiangling Su, Shixiong Cai, Chun Shi

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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  7. Brazilin cream fromPeerJ · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Wanhong ChenDepartment of Stomatology, Quanzhou First Hospital, Quanzhou, Fujian, China.
Jiangling SuDepartment of Stomatology, Quanzhou First Hospital, Quanzhou, Fujian, China.
Shixiong CaiDepartment of Stomatology, Quanzhou First Hospital, Quanzhou, Fujian, China.
Chun ShiDepartment of Endodontics and Periodontics, School of Stomatology, Dalian Medical University, Dalian, Liaoning, China.
Hangzhou First People's Hospital · CNDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is found that the activation of Sonic Hedgehog (SHH) signaling pathway is related to the degree of inflammation in patients suffering from periodontitis. Cullin3 (CUL3), an important ubiquitin ligase, can control SHH signaling. In this study, we were dedicated to clarify the roles of SHH and CUL3 in

Indexed as

Cullin ProteinsStem CellsCells, CulturedHedgehog ProteinsHumansInflammationLipopolysaccharidesNF-E2-Related Factor 2Periodontal LigamentSignal TransductionCUL3 protein, humanCullin ProteinsHedgehog ProteinsLipopolysaccharidesNFE2L2 protein, humanNF-E2-Related Factor 2CUL3inflammationPDLSCsP. gingivalis-LPSSHH

Identifiers

PMID34193016
PMCPMC8806625
OpenAlexW3177008423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.