ArticleNeuroImage. Clinical2021
Open science datasets from PREVENT-AD, a longitudinal cohort of pre-symptomatic Alzheimer's disease.
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Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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84citing papers in PubMed
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84 citing papers in PubMed.
- Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition.GeroScience · 2026Article
- Longitudinal changes in control energy of brain networks in older adults at familial risk for Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Reducing CETP activity prevents memory decline in an Alzheimer's disease mouse model.EMBO molecular medicine · 2026Article
- Genetic and molecular evidence linking CTSH to Alzheimer's disease pathophysiology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer's disease.Research square · 2026Article
- Parent-of-origin effects in Alzheimer's liability dissociate neurocognitive and cardiovascular traits in at-risk individuals.Cell reports. Medicine · 2026Article
- Elucidating the neuropathological and molecular heterogeneity of amyloid beta and tau in Alzheimer's disease through machine learning and transcriptomic integration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multi-domain AD risk burden and plasma biomarkers in cognitively unimpaired adults.medRxiv : the preprint server for health sciences · 2026Article
- Education, Cognitive Reserve, and Brain Pathology in Aging and Alzheimer's Disease: Evidence from Preclinical and Symptomatic Cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Open neuroinformatics infrastructure ecosystem for federated multisite studies.bioRxiv : the preprint server for biology · 2026Article
- Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions.Nature communications · 2026Article
- Longitudinal association between sleep and Alzheimer's pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A benchmark of text embedding models for semantic harmonization of Alzheimer's disease cohorts.The journal of prevention of Alzheimer's disease · 2025Article
- Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change.Nature communications · 2025Article
- Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults.Scientific reports · 2025Article
- Exploring sex-specific risk factors in cognitive decline: Insights into modifiable and non-modifiable determinants using a network analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The PREVENT-AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Calibration of multisite raters for prospective visual reads of amyloid PET scans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Tracking a decade of structural changes in preclinical and prodromal Alzheimer's disease: insights from amyloid-β pathology.medRxiv : the preprint server for health sciences · 2025Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
26 authors.
Jennifer Tremblay-MercierStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada. Electronic address: Jennifer.tremblay-mercier@douglas.mcgill.ca.
Cécile MadjarStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada. Electronic address: cecile.madjar@mcin.ca.
Samir DasMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada. Electronic address: samir.das@mcgill.ca.
Alexa Pichet BinetteStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada. Electronic address: alexa.pichetbinette@mail.mcgill.ca.
Stephanie O M DykeMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada. Electronic address: stephanie.dyke@mcgill.ca.
Pierre ÉtienneStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada. Electronic address: pierre.emile.etienne.med@ssss.gouv.qc.ca.
Marie-Elyse Lafaille-MagnanStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; Centre for Child Development and Mental Health, Jewish General Hospital. Montréal, QC, Canada. Electronic address: elyse.lafaille-magnan@mail.mcgill.ca.
Jordana RemzStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada. Electronic address: jordana.remz.comtl@ssss.gouv.qc.ca.
Pierre BellecCRIUGM - Université de Montréal, Montréal, QC, Canada; Université de Montréal, Montréal, QC, Canada. Electronic address: pierre.bellec@criugm.qc.ca.
D Louis CollinsMcGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada. Electronic address: louis.collins@mcgill.ca.
M Natasha RajahStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada. Electronic address: maria.rajah@mcgill.ca.
Veronique BohbotStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada. Electronic address: veronique.bohbot@mcgill.ca.
Jeannie-Marie LeoutsakosJohn Hopkins University School of Medicine, Baltimore, MD, USA,. Electronic address: jeannie-marie@jhu.edu.
Yasser Iturria-MedinaMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada. Electronic address: yasser.iturriamedina@mcgill.ca.
Justin KatStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada. Electronic address: justin.kat@mail.mcgill.ca.
Richard D HogeMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; Université de Montréal, Montréal, QC, Canada. Electronic address: rick.hoge@mcgill.ca.
Serge GauthierStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada. Electronic address: serge.gauthier@mcgill.ca.
Christine L TardifMcGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada. Electronic address: christine.tardif@mcgill.ca.
M Mallar ChakravartyStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada. Electronic address: mallar.chakravarty@douglas.mcgill.ca.
Jean-Baptiste PolineMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada. Electronic address: jean-baptiste.poline@mcgill.ca.
Pedro Rosa-NetoStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada. Electronic address: pedro.rosa@mcgill.ca.
Alan C EvansStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada. Electronic address: alan.evans@mcgill.ca.
Sylvia VilleneuveStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada. Electronic address: sylvia.villeneuve@mcgill.ca.
Judes PoirierStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada. Electronic address: judes.poirier@mcgill.ca.
John C S BreitnerStoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada. Electronic address: john.breitner@mcgill.ca.
PREVENT-AD Research Group
Funding
No grant is acknowledged in the PubMed record.
Abstract
To move Alzheimer Disease (AD) research forward it is essential to collect data from large cohorts, but also make such data available to the global research community. We describe the creation of an open science dataset from the PREVENT-AD (PResymptomatic EValuation of Experimental or Novel Treatments for AD) cohort, composed of cognitively unimpaired older individuals with a parental or multiple-sibling history of AD. From 2011 to 2017, 386 participants were enrolled (mean age 63 years old ± 5) for sustained investigation among whom 349 have retrospectively agreed to share their data openly. Repositories are findable through the unified interface of the Canadian Open Neuroscience Platform and contain up to five years of longitudinal imaging data, cerebral fluid biochemistry, neurosensory capacities, cognitive, genetic, and medical information. Imaging data can be accessed openly at https://openpreventad.loris.ca while most of the other information, sensitive by nature, is accessible by qualified researchers at https://registeredpreventad.loris.ca. In addition to being a living resource for continued data acquisition, PREVENT-AD offers opportunities to facilitate understanding of AD pathogenesis.
Indexed as
Alzheimer DiseaseAmyloid beta-PeptidesBiomarkersCanadaHumansMiddle AgedRetrospective Studiestau ProteinsAmyloid beta-PeptidesBiomarkerstau ProteinsBiomarkersCerebrospinal Fluid proteinsNeuroimagingObservational cohortOpen SciencePre-symptomatic Alzheimer Disease
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