Evidence map›Paper›PMID 34192546›Full record

ArticleCell reports2021

Stability of ripple events during task engagement in human hippocampus.

Yvonne Y Chen, Lyndsey Aponik-Gremillion, Eleonora Bartoli, Daniel Yoshor, Sameer A Sheth, Brett L Foster

Abstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Hippocampal Ripples during Offline Periods Predict Human Motor Sequence Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Human Hippocampal Ripples Signal Encoding of Episodic Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  18. Article
  19. Ripples in macaque V1 and V4 are modulated by top-down visual attention.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yvonne Y ChenDepartment of Neurosurgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Lyndsey Aponik-GremillionDepartment of Neurosurgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Eleonora BartoliDepartment of Neurosurgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Daniel YoshorDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Sameer A ShethDepartment of Neurosurgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Brett L FosterDepartment of Neurosurgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: brett.foster@pennmedicine.upenn.edu.

Funding

Visual Form Perception Produced by Electrically Stimulating Human Visual CortexR01EY023336 · NEI · UNIVERSITY OF PENNSYLVANIA · PI DANIEL YOSHOR · 2013 to 2026
$5.3M
Sensory Reinstatement in Human NeocortexR01MH116914 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FOSTER, BRETT · 2018 to 2022
$2.0M
COGNITIVE CONTROL MECHANISMS IN HUMAN PREFRONTAL CORTEXR01MH106700 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHETH, SAMEER ANIL · 2016 to 2020
$1.6M
NEI NIH HHS R01 EY023336NIMH NIH HHS R01 MH106700NIMH NIH HHS R01 MH116914
6 · The paper itself

Abstract

High-frequency activity bursts in the hippocampus, known as ripples, are thought to support memory consolidation during "offline" states, such as sleep. Recently, human hippocampal ripples have been observed during "online" episodic memory tasks. It remains unclear whether similar ripple activity occurs during other cognitive states, including different types of episodic memory. However, identifying genuine ripple events in the human hippocampus is challenging. To address these questions, spectro-temporal ripple identification was applied to human hippocampal recordings across a variety of cognitive tasks. Overall, ripple attributes were stable across tasks of visual perception and associative memory, with mean rates lower than offline states of rest and sleep. In contrast, while more complex visual attention tasks did not modulate ripple attributes, rates were enhanced for more complex autobiographical memory conditions. Therefore, hippocampal ripples reliably occur across cognitive states but are specifically enhanced during offline states and complex memory processes, consistent with a role in consolidation.

Indexed as

Task Performance and AnalysisAction PotentialsAdultArtifactsCognitionElectrodesFemaleHippocampusHumansMaleMemory, EpisodicMiddle AgedSleepTime FactorsYoung AdulthippocampusiEEGmemoryperceptionripplessleep

Identifiers

PMID34192546
PMCPMC8288441

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.