Evidence map›Paper›PMID 34192542›Full record

ArticleCell reports2021

Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation.

James H Baraniak, Yandong Zhou, Robert M Nwokonko, Michelle R Jennette, Sarah A Kazzaz, Jazmin M Stenson, Abigale L Whitsell, Youjun Wang, Mohamed Trebak, Donald L Gill

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. ORAI CaBiomolecules · 2024
    Review
  4. Article
  5. Neuronal Store-Operated Calcium Channels.Molecular neurobiology · 2023
    Review
  6. Review
  7. Review
  8. Review
  9. Dysregulated CaCells · 2022
    Review
  10. Review
  11. Review
  12. Article
  13. STIM Proteins: An Ever-Expanding Family.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

James H BaraniakDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Yandong ZhouDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. Electronic address: zhouyd@psu.edu.
Robert M NwokonkoDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Michelle R JennetteDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Sarah A KazzazDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Jazmin M StensonDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Abigale L WhitsellDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Youjun WangBeijing Key Laboratory of Gene Resources and Molecular Development College of Life Sciences, Beijing Normal University, Beijing 100875, People's Republic of China.
Mohamed TrebakDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Donald L GillDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. Electronic address: dongill@psu.edu.
Pennsylvania State University · US

Funding

Ca2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4M
Understanding Store-Operated Calcium Signal TransductionR35GM131916 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2019 to 2023
$2.9M
Calcium Signaling Roles of STIM1 and STIM2 in Smooth MuscleR01GM109279 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2014 to 2017
$1.6M
Control of Calcium Entry Signals in B CellsR01GM120783 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2016 to 2018
$1.3M
Understanding Spatial Interactions Between STIM and OraiF31GM125376 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI NWOKONKO, ROBERT M · 2017 to 2018
$61k
The STIM/Orai interface and novel tools to control vascular smooth muscle phenotypeF31HL152619 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BARANIAK, JAMES HENRY · 2020 to 2021
$50k
NHLBI NIH HHS F31 HL152619NHLBI NIH HHS R35 HL150778NIGMS NIH HHS F31 GM125376NIGMS NIH HHS R01 GM109279NIGMS NIH HHS R01 GM120783NIGMS NIH HHS R35 GM131916
6 · The paper itself

Abstract

Junctional coupling between endoplasmic reticulum (ER) Ca

Indexed as

Calcium SignalingAmino Acid SequenceBinding SitesBoron CompoundsCalcium ChannelsCell MembraneCytosolEndoplasmic ReticulumHEK293 CellsHeLa CellsHumansIon Channel GatingLeucineModels, MolecularMutationNFATC Transcription Factors2-aminoethoxydiphenyl borateBoron CompoundsCalcium ChannelsLeucineNFATC Transcription FactorsORAI1 ProteinOrai3 protein, humanPeptidesStromal Interaction Molecule 1

Identifiers

PMID34192542
PMCPMC8462482
OpenAlexW3173828438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.