Evidence map›Paper›PMID 34192507›Full record

ArticleAmerican journal of respiratory cell and molecular biology2021

Hypercapnia Induces Inositol-Requiring Enzyme 1α-Driven Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase β-Subunit.

Vitalii Kryvenko, Miriam Wessendorf, Khodr Tello, Susanne Herold, Rory E Morty, Werner Seeger, István Vadász

Abstract read
PubMed Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Hypercapnia Effects on Lung Function.Comprehensive Physiology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. In Search of a Sensor: How Does COAmerican journal of respiratory cell and molecular biology · 2021
    Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Vitalii KryvenkoDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
Miriam WessendorfDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
Khodr TelloDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
Susanne HeroldDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
Rory E MortyDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
Werner SeegerDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
István VadászDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.ORCID 0000-0003-1370-9783
German Center for Lung Research · DEMax Planck Institute for Heart and Lung Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute respiratory distress syndrome is often associated with elevated levels of CO

Indexed as

Endoplasmic Reticulum-Associated DegradationA549 CellsAnimalsEndoplasmic ReticulumEndoribonucleasesHumansHypercapniaMiceProtein Serine-Threonine KinasesSodium-Potassium-Exchanging ATPaseATP1B1 protein, humanAtp1b1 protein, mouseEndoribonucleasesERN1 protein, humanErn1 protein, mouseProtein Serine-Threonine KinasesSodium-Potassium-Exchanging ATPasealveolar epitheliumcarbon dioxideendoplasmic reticulum–associated degradationNa,K-ATPasesodium transport

Identifiers

PMID34192507
OpenAlexW3177014362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.