Evidence map›Paper›PMID 34192504›Full record

ArticlemSphere2021

Competence-Associated Peptide BriC Alters Fatty Acid Biosynthesis in Streptococcus pneumoniae.

Surya D Aggarwal, Jessica M Gullett, Tara Fedder, J Pedro F Safi, Charles O Rock, N Luisa Hiller

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Colonization dynamics ofInfection and immunity · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Streptococcal peptides and their roles in host-microbe interactions.Frontiers in cellular and infection microbiology · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Gene Expression Regulation in Airway Pathogens: Importance for Otitis Media.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Surya D AggarwalDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Jessica M GullettDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Tara FedderDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
J Pedro F SafiDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Charles O RockDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
N Luisa HillerDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Carnegie Mellon University · USSt. Jude Children's Research Hospital · US

Funding

REGULATION OF LIPID METABOLISM IN E COLIR01GM034496 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ROCK, CHARLES O · 1985 to 2022
$9.2M
REGULATION OF LIPID METABOLISM IN BACTERIAR37GM034496 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ROCK, CHARLES O · 2001 to 2010
$5.7M
Deciphering the Role of Rgg in the Pneumococcal Signaling, Colonization and Virulence PortfolioR01AI139077 · NIAID · CARNEGIE-MELLON UNIVERSITY · PI HILLER, NATALIA LUISA · 2019 to 2023
$1.9M
NIAID NIH HHS R01 AI139077NIGMS NIH HHS R01 GM034496NIGMS NIH HHS R37 GM034496
6 · The paper itself

Abstract

Membrane lipid homeostasis is required for bacteria to survive in a spectrum of host environments. This homeostasis is achieved by regulation of fatty acid chain length and of the ratio of unsaturated to saturated fatty acids. In the pathogen Streptococcus pneumoniae, fatty acid biosynthesis is carried out by a cluster of fatty acid biosynthesis (

Indexed as

Adaptation, PhysiologicalBacterial ProteinsBiofilmsBiosynthetic PathwaysFatty AcidsGene Expression Regulation, BacterialMultigene FamilyMutationPneumococcal InfectionsStreptococcus pneumoniaeBacterial ProteinsFatty Acidsbiofilmscell-cell communicationcompetencefatty acid biosynthesismembrane phospholipid compositionStreptococcus pneumoniae

Identifiers

PMID34192504
PMCPMC8265628
OpenAlexW3169485109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.