Evidence map›Paper›PMID 34192392›Full record

ArticleTropical medicine & international health : TM & IH2021

Catastrophic costs among tuberculosis-affected households in Zimbabwe: A national health facility-based survey.

Collins Timire, Mkhokheli Ngwenya, Joconiah Chirenda, John Z Metcalfe, Katharina Kranzer, Debora Pedrazzoli, Kudakwashe C Takarinda, Peter Nguhiu, Geshem Madzingaidzo, Kwenzikweyinkosi Ndlovu and 3 more

Abstract read
In one paragraph

Article in Tropical medicine & international health : TM & IH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Collins TimireAIDS & TB Control Programme, Ministry of Health and Child Care, Harare, Zimbabwe.ORCID 0000-0003-0997-9799
Mkhokheli NgwenyaZimbabwe Country Office, World Health Organization, Harare, Zimbabwe.
Joconiah ChirendaCollege of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.ORCID 0000-0003-2441-3304
John Z MetcalfeDivision of Pulmonary and Critical Care Medicine, Zuckerberg San Francisco General Hospital and Trauma Center, University of California, San Francisco, CA, USA.
Katharina KranzerFaculty of Infectious & Tropical Diseases, London School of Hygiene &Tropical Medicine, London, UK.ORCID 0000-0001-5691-7270
Debora PedrazzoliFaculty of Epidemiology & Population Health, London School of Hygiene &Tropical Medicine, London, UK.
Kudakwashe C TakarindaAIDS & TB Control Programme, Ministry of Health and Child Care, Harare, Zimbabwe.ORCID 0000-0002-2980-7735
Peter NguhiuHealth Economics Research Unit, Kenya Medical Research Institute, Wellcome Trust Research Programme, Nairobi, Kenya.ORCID 0000-0002-0875-0549
Geshem MadzingaidzoAIDS & TB Control Programme, Ministry of Health and Child Care, Harare, Zimbabwe.
Kwenzikweyinkosi NdlovuAIDS & TB Control Programme, Ministry of Health and Child Care, Harare, Zimbabwe.
Tawanda MapurangaAIDS & TB Control Programme, Ministry of Health and Child Care, Harare, Zimbabwe.
Morna CornellCentre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-7149-8799
Charles SandyAIDS & TB Control Programme, Ministry of Health and Child Care, Harare, Zimbabwe.ORCID 0000-0003-0264-7900

Funding

Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
Training for Research Excellence and MeNtorship in Tuberculosis (TRENT)D43TW009539 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI METCALFE, JOHN ZAPATA · 2013 to 2022
$2.9M
FIC NIH HHS D43 TW009539NIAID NIH HHS U01 AI069924World Health Organization 001
6 · The paper itself

Abstract

objectivesTo determine the incidence and major drivers of catastrophic costs among TB-affected households in Zimbabwe.

methodsWe conducted a nationally representative health facility-based survey with random cluster sampling among consecutively enrolled drug-susceptible (DS-TB) and drug-resistant TB (DR-TB) patients. Costs incurred and income lost due to TB illness were captured using an interviewer-administered standardised questionnaire. We used multivariable logistic regression to determine the risk factors for experiencing catastrophic costs.

resultsA total of 841 patients were enrolled and were weighted to 900 during data analysis. There were 500 (56%) males and 46 (6%) DR-TB patients. Thirty-five (72%) DR-TB patients were HIV co-infected. Overall, 80% (95% CI: 77-82) of TB patients and their households experienced catastrophic costs. The major cost driver pre-TB diagnosis was direct medical costs. Nutritional supplements were the major cost driver post-TB diagnosis, with a median cost of US$360 (IQR: 240-600). Post-TB median diagnosis costs were three times higher among DR-TB (US$1,659 [653-2,787]) than drug DS-TB-affected households (US$537 [204-1,134]). Income loss was five times higher among DR-TB than DS-TB patients. In multivariable analysis, household wealth was the only covariate that remained significantly associated with catastrophic costs: The poorest households had 16 times the odds of incurring catastrophic costs versus the wealthiest households (adjusted odds ratio [aOR: 15.7 95% CI: 7.5-33.1]).

conclusionThe majority of TB-affected households, especially those affected by DR-TB, experienced catastrophic costs. Since the major cost drivers fall outside the healthcare system, multi-sectoral approaches to TB control and linking TB patients to social protection may reduce catastrophic costs.

Indexed as

Health Care CostsHealth ExpendituresAdolescentAdultAgedAntitubercular AgentsFamily CharacteristicsFemaleHumansMaleMiddle AgedTuberculosisYoung AdultZimbabweAntitubercular Agentsfinancial protectionpatient costsocial protectiontuberculosisuniversal health coverageZimbabwe

Identifiers

PMID34192392
PMCPMC8519355

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.