Evidence map›Paper›PMID 34192318›Full record

ArticleGlycobiology2021

Are sialic acids involved in COVID-19 pathogenesis?

Chirag Dhar, Aniruddha Sasmal, Sandra Diaz, Andrea Verhagen, Hai Yu, Wanqing Li, Xi Chen, Ajit Varki

Open access · bronzeAbstract readComment
In one paragraph

Article in Glycobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. The HCoV-HKU1 N-terminal domain binds a wide range of 9-bioRxiv : the preprint server for biology · 2024
    Article
  4. Article
  5. Article
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  7. Article
  8. Biochemistry · 2022
    Article
  9. Article
  10. Article
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  12. Article
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  14. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chirag DharDepartments of Medicine and Cellular and Molecular Medicine, UC San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Aniruddha SasmalDepartments of Medicine and Cellular and Molecular Medicine, UC San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Sandra DiazDepartments of Medicine and Cellular and Molecular Medicine, UC San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Andrea VerhagenDepartments of Medicine and Cellular and Molecular Medicine, UC San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Hai YuDepartment of Chemistry, 1 Shields Ave, Davis, CA, USA.
Wanqing LiDepartment of Chemistry, 1 Shields Ave, Davis, CA, USA.
Xi ChenDepartment of Chemistry, 1 Shields Ave, Davis, CA, USA.
Ajit VarkiDepartments of Medicine and Cellular and Molecular Medicine, UC San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
University of California, San Diego · USSHIELDS for Families · US

Funding

BIOSYNTHESIS AND REGULATION OF SUBSTITUTED SIALIC ACIDSR01GM032373 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARKI, AJIT P · 1985 to 2022
$6.9M
Supplement: Exploring the biology of O-acetyl sialic acids using stable synthetic mimicsR01AI130684 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XI, VARKI, AJIT P · 2017 to 2020
$2.3M
NIAID NIH HHS R01 AI130684NIGMS NIH HHS R01 GM032373
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19Sialic AcidsHumansSARS-CoV-2Sialic Acids

Identifiers

PMID34192318
PMCPMC8344891
OpenAlexW3176260412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.