Evidence map›Paper›PMID 34192289›Full record

ReviewAmerican heart journal plus : cardiology research and practice2021

Post-Acute COVID-19 Syndrome and the cardiovascular system: What is known?

Neal M Dixit, Austin Churchill, Ali Nsair, Jeffrey J Hsu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American heart journal plus : cardiology research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.

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  18. Cardiovascular effects of the post-COVID-19 condition.Nature cardiovascular research · 2024
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Neal M DixitDepartment of Medicine, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Los Angeles, CA 90095, USA.
Austin ChurchillSchool of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.
Ali NsairDepartment of Medicine, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Los Angeles, CA 90095, USA.
Jeffrey J HsuDepartment of Medicine, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Los Angeles, CA 90095, USA.
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-Acute COVID-19 Syndrome (PACS) is defined by persistent symptoms >3-4 weeks after onset of COVID-19. The mechanism of these persistent symptoms is distinct from acute COVID-19 although not completely understood despite the high incidence of PACS. Cardiovascular symptoms such as chest pain and palpitations commonly occur in PACS, but the underlying cause of symptoms is infrequently known. While autopsy studies have shown that the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) rarely causes direct myocardial injury, several syndromes such as myocarditis, pericarditis, and Postural Orthostatic Tachycardia Syndrome have been implicated in PACS. Additionally, patients hospitalized with acute COVID-19 who display biomarker evidence of myocardial injury may have underlying coronary artery disease revealed by the physiological stress of SARS-CoV-2 infection and may benefit from medical optimization. We review what is known about PACS and the cardiovascular system and propose a framework for evaluation and management of related symptoms.

Indexed as

ACE2, angiotensin converting enzyme-2AF/AFL, atrial fibrillation or flutterCardiologyCBT, cognitive behavioral therapyCFS, Chronic Fatigue SyndromeCMR, cardiac magnetic resonance imagingCoronavirus Disease 2019CRP, C-reactive proteinCV, cardiovascularECG, electrocardiographyECV, extracellular volumeLGE, late gadolinium enhancementLong COVIDLong-Haul COVIDMCAS, Mast Cell Activation SyndromeMERS, Middle East Respiratory SyndromePOTS, Post-Acute COVID-19 SyndromeSARS-COV-1, Severe Acute Respiratory Syndrome Coronavirus-1SARS-CoV-2T1MI, type 1 myocardial infarctionT2MI, type 2 myocardial infarctionTTT, tilt table testing

Identifiers

PMID34192289
PMCPMC8223036
OpenAlexW3173634136

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.