ArticleQRB discovery2020
A 3.4-Å cryo-electron microscopy structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles.
Open access · goldAbstract read
In one paragraph
Article in QRB discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Mutations to the HCoV-229E spike have counterbalancing effects on serum antibody neutralization and receptor binding.bioRxiv : the preprint server for biology · 2026Article
- Q-score as a reliability measure for protein, nucleic acid and small-molecule atomic coordinate models derived from 3DEM maps.Acta crystallographica. Section D, Structural biology · 2025Article
- Single-particle cryogenic electron microscopy structure determination for membrane proteins.Current opinion in structural biology · 2025Review
- Comprehensive analysis of human coronavirus antibody responses in ICU and non-ICU COVID-19 patients reveals IgG3 against SARS-CoV-2 spike protein as a key biomarker of disease severity.Journal of medical microbiology · 2025Article
- Molecular basis of host recognition of human coronavirus 229E.Nature communications · 2025Article
- Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses.PLoS pathogens · 2024Article
- Discordant phylodynamic and spatiotemporal transmission patterns driving the long-term persistence and evolution of human coronaviruses.Npj viruses · 2024Article
- Structural proteins of human coronaviruses: what makes them different?Frontiers in cellular and infection microbiology · 2024Review
- Structural insights into the modulation of coronavirus spike tilting and infectivity by hinge glycans.Nature communications · 2023Article
- The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition.FEBS open bio · 2022Review
- In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM.Nature communications · 2022Article
- Review
- Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection.Cell reports methods · 2022Article
- Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection.bioRxiv : the preprint server for biology · 2022Article
- Sub-3 Å Cryo-EM Structures of Necrosis Virus Particles via the Use of Multipurpose TEM with Electron Counting Camera.International journal of molecular sciences · 2021Article
- Targeting ACE2 for COVID-19 Therapy: Opportunities and Challenges.American journal of respiratory cell and molecular biology · 2021Review
Corrections and comments
- Update of
Authors and funding
8 authors at 4 institutions in 1 country.
Kaiming ZhangDepartment of Bioengineering and James H. Clark Center, Stanford University, Stanford, CA 94305, USA.ORCID https://orcid.org/0000-0003-0414-4776
Shanshan LiDepartment of Bioengineering and James H. Clark Center, Stanford University, Stanford, CA 94305, USA.ORCID https://orcid.org/0000-0002-7041-5960
Grigore PintilieDepartment of Bioengineering and James H. Clark Center, Stanford University, Stanford, CA 94305, USA.ORCID https://orcid.org/0000-0002-0848-5335
David ChmielewskiGraduate Program in Biophysics, Stanford University, Stanford, CA 94305, USA.ORCID https://orcid.org/0000-0002-4498-7949
Michael F SchmidDivision of CryoEM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.ORCID https://orcid.org/0000-0003-1077-5750
Graham SimmonsVitalant Research Institute, San Francisco, CA 94030, USA.ORCID https://orcid.org/0000-0002-9615-7023
Jing JinVitalant Research Institute, San Francisco, CA 94030, USA.ORCID https://orcid.org/0000-0003-3994-8600
Wah ChiuDepartment of Bioengineering and James H. Clark Center, Stanford University, Stanford, CA 94305, USA.ORCID https://orcid.org/0000-0002-8910-3078
Clark University · USSLAC National Accelerator Laboratory · USPacific Research Institute · USStanford University · US
Funding
Virology BSL4 CoreP01AI120943 · NIAID · WASHINGTON UNIVERSITY · PI Gaya K. Amarasinghe · 2016 to 2026
$30.2M3 D ELECTRON MICROSCOPY OF MACROMOLECULES (5P41RR002250-27)P41GM103832 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2012 to 2019
$15.1MUnified Data Resource for Large Complexes Determined by Cryo-Electron MicroscopyR01GM079429 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2007 to 2021
$11.6MHOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0MMolecular Interactions of HIV-1 with the Nuclear Pore ComplexR01AI148382 · NIAID · EMORY UNIVERSITY · PI MELIKIAN, GREGORY B, SARAFIANOS, STEFAN G · 2019 to 2022
$5.5MElectron transfer activity of mitoNEET and regulation of energy metabolism in mitochondriaR15GM129564 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI DING, HUANGEN · 2018 to 2018
$433kNIAID NIH HHS P01 AI120943NIAID NIH HHS R01 AI148382NIGMS NIH HHS P41 GM103832NIGMS NIH HHS R01 GM079429NIGMS NIH HHS R15 GM129564NIGMS NIH HHS T32 GM008280
Abstract
Human coronavirus NL63 (HCoV-NL63) is an enveloped pathogen of the family
Indexed as
Cryo-EMhuman coronavirus NL63spike trimer
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.