ArticleBMJ paediatrics open2021
Predictors of serious bacterial infections using serum biomarkers in an infant population aged 0 to 90 days: a prospective cohort study.
Article in BMJ paediatrics open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Determinants of expert-advised antibiotic indication in pediatric emergency department, data from a cross-sectional prevalence survey.BMC pediatrics · 2026Article
- Identifying the thresholds of C-reactive protein, procalcitonin, and interleukin-6 among children ≤36 months' old with fever without source at risk of serious bacterial infections: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Diagnostic multiparametric models and antibiotic practices in febrile infants younger than 90 days.European journal of pediatrics · 2025Observational
- Factors associated with severe bacterial infection in infants between 91- and 120-days old admitted to the pediatric emergency department.BMC pediatrics · 2025Article
- Predicting purulent meningitis in very preterm infants: a novel clinical model.BMC pediatrics · 2025Article
- Utility of interleukin-6 to identify serious bacterial infections in febrile infants aged ≤60 days.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Article
- Nisin-preconditioned mesenchymal stem cells combatting nosocomialRegenerative therapy · 2024Article
- Protocol for the diagnostic performance of C reactive protein, procalcitonin and interleukin-6 for serious bacterial infections among children ≤36 months old presenting with fever without source: a systematic review and meta-analysis.BMJ paediatrics open · 2024Article
- Antimicrobial Stewardship in Pediatric Emergency Medicine: A Narrative Exploration of Antibiotic Overprescribing, Stewardship Interventions, and Performance Metrics.Children (Basel, Switzerland) · 2024Review
- Febrile children with comorbidities at the emergency department - a multicentre observational study.European journal of pediatrics · 2022Observational
- Establishment of a predictive model for purulent meningitis in preterm infants.Translational pediatrics · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Young febrile infants represent a vulnerable population at risk for serious bacterial infections (SBI). We aimed to evaluate the diagnostic accuracy of components of the complete blood count in comparison with C-reactive protein (CRP) to predict SBI among febrile infants. Design and setting: Prospective cohort study conducted in a tertiary emergency department between December 2018 and November 2019. Patients: We included febrile infants ≤3 months old with complete blood count results. We analysed their white blood cell count (WBC), absolute neutrophil ratio (ANC), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio, mean platelet volume to platelet count ratio, and compared these to the performance of CRP. Main outcome measures: SBIs were defined as urinary tract infection, bacteraemia, bacterial meningitis, sepsis, pneumonia, skin and soft tissue infection, bacterial enteritis, septic arthritis or osteomyelitis. Results: Of the 187 infants analysed, 54 (28.9%) were diagnosed with SBI. Median values of WBC, ANC, NLR and CRP were significantly higher in infants with SBI: WBC (13.8 vs 11.4×10 Conclusion: In young febrile infants, CRP was the best discriminatory biomarker for SBI. WBC, ANC and NLR when used in combination have potential diagnostic utility in this population.
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