Evidence map›Paper›PMID 34192060›Full record

ArticleJournal of clinical and translational science2021

Prioritizing studies of COVID-19 and lessons learned.

Dushyantha Jayaweera, Patrick A Flume, Nora G Singer, Myron S Cohen, Anne M Lachiewicz, Amanda Cameron, Naresh Kumar, Joel Thompson, Alyssa Cabrera, Denise Daudelin and 2 more

Abstract read
In one paragraph

Article in Journal of clinical and translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Impact of the COVID-19 pandemic on CTSA Clinical Research Centers over 2 years.Journal of clinical and translational science · 2023
    Article
  5. Review
  6. Review
  7. Conducting clinical research in the era of the COVID-19 pandemic: Challenges and lessons for Speech-Language Pathology and Audiology research.The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Managing the risks and benefits of clinical research in response to a pandemic.Journal of clinical and translational science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dushyantha JayaweeraUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Patrick A FlumeMedical University of South Carolina, Charleston, SC, USA.
Nora G SingerThe MetroHealth System at Case Western Reserve University, Cleveland, OH, USA.
Myron S CohenThe University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Anne M LachiewiczThe University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Amanda CameronMedical University of South Carolina, Charleston, SC, USA.
Naresh KumarUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Joel ThompsonUniversity of Kentucky, Lexington, KY, USA.
Alyssa CabreraTufts Medical Center, Boston, MA, USA.
Denise DaudelinTufts Medical Center, Boston, MA, USA.
Reza ShakerMedical College of Wisconsin, Milwaukee, WI, USA.
Philippe R BauerMayo Clinic, Rochester, MN, USA.

Funding

Tufts Clinical and Translational Science Institute (Pilot Supplement)UL1TR002544 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2018 to 2022
$50.2M
Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
CTSA Coordinating Center for Leading Innovation and Collaboration (CLIC)U24TR002260 · NCATS · UNIVERSITY OF ROCHESTER · PI OSSIP, DEBORAH J, ZAND, MARTIN S · 2017 to 2021
$19.0M
NCATS NIH HHS U24 TR002260NCATS NIH HHS UL1 TR001436NCATS NIH HHS UL1 TR001450NCATS NIH HHS UL1 TR002544NCATS NIH HHS UL1 TR002548
6 · The paper itself

Abstract

introductionCOVID-19 altered research in Clinical and Translational Science Award (CTSA) hubs in an unprecedented manner, leading to adjustments for COVID-19 research.

methodsCTSA members volunteered to conduct a review on the impact of CTSA network on COVID-19 pandemic with the assistance from NIH survey team in October 2020. The survey questions included the involvement of CTSAs in decision-making concerning the prioritization of COVID-19 studies. Descriptive and statistical analyses were conducted to analyze the survey data.

results60 of the 64 CTSAs completed the survey. Most CTSAs lacked preparedness but promptly responded to the pandemic. Early disruption of research triggered, enhanced CTSA engagement, creation of dedicated research areas and triage for prioritization of COVID-19 studies. CTSAs involvement in decision-making were 16.75 times more likely to create dedicated diagnostic laboratories (95% confidence interval [CI] = 2.17-129.39;

conclusionsThe lessons learned from the COVID-19 pandemic emphasize the pivotal role of CTSAs in prioritizing studies and establishing the necessary research infrastructure, and the importance of prompt and flexible research leadership with decision-making capacity to manage future pandemics.

Indexed as

Clinical translational researchCOVID-19CTSAleadershiplessons learned

Identifiers

PMID34192060
PMCPMC8185424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.