Evidence map›Paper›PMID 34192045›Full record

ArticleJournal of clinical and translational science2020

Effect of various decontamination procedures on disposable N95 mask integrity and SARS-CoV-2 infectivity.

Jeffrey S Smith, Haley Hanseler, John Welle, Rogan Rattray, Mary Campbell, Tacy Brotherton, Tarsem Moudgil, Thomas F Pack, Keith Wegmann, Shawn Jensen and 5 more

Abstract read
In one paragraph

Article in Journal of clinical and translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. The COVID-19 pandemic and N95 masks: reusability and decontamination methods.Antimicrobial resistance and infection control · 2021
    Pooled it
  3. Pooled it
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  8. Evaluation of the effectiveness of UV-C dose for photoinactivation of SARS-CoV-2 in contaminated N95 respirator, surgical and cotton fabric masks.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jeffrey S SmithProvidence Portland Medical Center, Department of Medicine, Portland, Oregon, USA.
Haley HanselerOHSU Medical School, Portland, Oregon, USA.
John WelleRegional Pathology, Providence St. Joseph Health, Portland, Oregon, USA.
Rogan RattrayRegional Pathology, Providence St. Joseph Health, Portland, Oregon, USA.
Mary CampbellRegional Pathology, Providence St. Joseph Health, Portland, Oregon, USA.
Tacy BrothertonCancer Research Animal Division, Robert W. Franz Cancer Center, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, Oregon, USA.
Tarsem MoudgilMolecular & Tumor Immunology, Robert W. Franz Cancer Center, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, Oregon, USA.
Thomas F PackAxovant Gene Therapies, Ltd, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-1240-8324
Keith WegmannMolecular & Tumor Immunology, Robert W. Franz Cancer Center, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, Oregon, USA.
Shawn JensenMolecular & Tumor Immunology, Robert W. Franz Cancer Center, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, Oregon, USA.
Justin JinProvidence Portland Medical Center, Department of Medicine, Portland, Oregon, USA.
Carlo B BifulcoRegional Pathology, Providence St. Joseph Health, Portland, Oregon, USA.
Scott A PrahlElectrical Engineering and Renewable Energy, Oregon Institute of Technology, Wilsonville, Oregon, USA.
Bernard A FoxMolecular & Tumor Immunology, Robert W. Franz Cancer Center, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, Oregon, USA.
Nicholas L StuckyProvidence Portland Medical Center, Department of Medicine, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-6610-5353

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe COVID-19 pandemic has created a high demand on personal protective equipment, including disposable N95 masks. Given the need for mask reuse, we tested the feasibility of vaporized hydrogen peroxide (VHP), ultraviolet light (UV), and ethanol decontamination strategies on N95 mask integrity and the ability to remove the infectious potential of SARS-CoV-2.

methodsDisposable N95 masks, including medical grade (1860, 1870+) and industrial grade (8511) masks, were treated by VHP, UV, and ethanol decontamination. Mask degradation was tested using a quantitative respirator fit testing. Pooled clinical samples of SARS-CoV-2 were applied to mask samples, treated, and then either sent immediately for real-time reverse transcriptase-polymerase chain reaction (RT-PCR) or incubated with Vero E6 cells to assess for virucidal effect.

resultsBoth ethanol and UV decontamination showed functional degradation to different degrees while VHP treatment showed no significant change after two treatments. We also report a single SARS-CoV-2 virucidal experiment using Vero E6 cell infection in which only ethanol treatment eliminated detectable SARS-CoV-2 RNA.

conclusionsWe hope our data will guide further research for evidenced-based decisions for disposable N95 mask reuse and help protect caregivers from SARS-CoV-2 and other pathogens.

Indexed as

COVID-19Infectious diseasesmask decontaminationN95SARS-CoV-2ultraviolet germicidal irradiationvaporized hydrogen peroxide

Identifiers

PMID34192045
PMCPMC7605403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.