Evidence map›Paper›PMID 34191826›Full record

Observational studyPloS one2021

Association of CYP24A1 gene polymorphism with colorectal cancer in the Jiamusi population.

Lin Chai, Jian Ni, Xiaolin Ni, Nan Zhang, Yang Liu, Zhiwu Ji, Xingwang Zhao, Xiaowen Zhu, Bin Zhao, Guorong Xin and 9 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Lin ChaiThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Jian NiThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Xiaolin NiThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Beijing, P.R. China.
Nan ZhangThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Beijing, P.R. China.
Yang LiuThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Zhiwu JiThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Xingwang ZhaoThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Xiaowen ZhuThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Bin ZhaoThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Guorong XinThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Yu WangThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Fan YangThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Liang SunThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Beijing, P.R. China.
Xiaoquan ZhuThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Beijing, P.R. China.
Wenhua BaoThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Xiaofang ShuiThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Fengling WangThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Fujun ChenThe First Affiliated Hospital of Jiamusi University, Heilongjiang, P.R. China.
Ze YangThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Beijing, P.R. China.ORCID 0000-0003-4312-1454
First Affiliated Hospital of Jiamusi University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe population in Jiamusi has been reported to have the highest prevalence of colorectal cancer (CRC) in China. The genetic causal-effect for this occurrence among the residents remains unclear. Given the long cold seasons with people wearing more clothes and reduced UV exposure, we aimed to study the association between the vitamin D metabolism-related gene CYP24A1 polymorphism and CRC susceptibility.

methodA case-control study was conducted that included 168 patients with CRC and 710 age-matched healthy individuals as the control group. Plausible susceptible variations were sought and clinical phenotypic-genotype association analysis was performed.

resultsOverall, two CYP24A1 polymorphisms, rs6013905 AX (P = 0.02, OR = 1.89, 95%CI: 1.09-3.29) and rs2762939 GX (P = 0.02, OR = 1.52, 95%CI: 1.08-2.13) were significantly associated with CRC in the Jiamusi population. In the female group, three CYP24A1 polymorphisms, rs6013905 AX (P = 0.04, OR = 2.59, 95%CI: 1.03-6.49), rs2762939 GX (P = 0.01, OR = 2.35, 95%CI: 1.25-4.42), and rs6068816 GG (P = 0.05, OR = 1.89, 95%CI: 0.99-3.59) carriers were significantly associated with CRC. In clinical phenotypic-genotype analysis, rs6013905 GG (P = 0.05, OR = 4.00, 95%CI: 0.92-17.48) and rs2762939 GX (P = 0.03, OR = 4.87, 95%CI: 1.00-23.69) carriers were significantly associated with poorly differentiated CRC, while CYP24A1 rs6068816 AX was significantly associated with the tumor type (P = 0.02, OR = 2.08, 95%CI: 1.10-3.96) and location (P = 0.04, OR = 2.24, 95%CI: 1.05-4.77).

conclusionCYP24A1 gene polymorphism may be a genetic risk factor attributable to the highest prevalence of CRC in Jiamusi people. Individuals with CYP24A1 gene polymorphism may have an increased barrier for vitamin D absorption, thus contributing to the risk of CRC development.

Indexed as

Genetic Predisposition to DiseaseAllelesCase-Control StudiesChinaColorectal NeoplasmsFemaleGastrointestinal AbsorptionHeterozygoteHumansLinkage DisequilibriumMaleMiddle AgedOdds RatioPolymorphism, Single NucleotidePrevalenceVitamin DCYP24A1 protein, humanVitamin DVitamin D3 24-Hydroxylase

Identifiers

PMID34191826
PMCPMC8244863
OpenAlexW3173512656

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.