Evidence map›Paper›PMID 34191660›Full record

ArticleTechnology in cancer research & treatment

Deep Learning Models for Gastric Signet Ring Cell Carcinoma Classification in Whole Slide Images.

Fahdi Kanavati, Shin Ichihara, Michael Rambeau, Osamu Iizuka, Koji Arihiro, Masayuki Tsuneki

Open access · goldAbstract read
In one paragraph

Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fahdi KanavatiMedmain Research, Medmain Inc., Fukuoka, Japan.
Shin IchiharaDepartment of Surgical Pathology, Sapporo Kosei General Hospital, Sapporo, Hokkaido, Japan.
Michael RambeauMedmain Inc., Fukuoka, Japan.
Osamu IizukaMedmain Inc., Fukuoka, Japan.
Koji ArihiroDepartment of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan.
Masayuki TsunekiMedmain Research, Medmain Inc., Fukuoka, Japan.ORCID 0000-0003-3409-5485
Hiroshima University Hospital · JPSapporo Kosei General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Signet ring cell carcinoma (SRCC) of the stomach is a rare type of cancer with a slowly rising incidence. It tends to be more difficult to detect by pathologists, mainly due to its cellular morphology and diffuse invasion manner, and it has poor prognosis when detected at an advanced stage. Computational pathology tools that can assist pathologists in detecting SRCC would be of a massive benefit. In this paper, we trained deep learning models using transfer learning, fully-supervised learning, and weakly-supervised learning to predict SRCC in Whole Slide Images (WSIs) using a training set of 1,765 WSIs. We evaluated the models on two different test sets (n = 999, n = 455). The best model achieved a ROC-AUC of at least 0.99 on all two test sets, setting a top baseline performance for SRCC WSI classification.

Indexed as

Deep LearningArea Under CurveCarcinoma, Signet Ring CellComputational BiologyFalse Negative ReactionsFalse Positive ReactionsHumansROC CurveStomach NeoplasmsSupervised Machine Learningdeep learninggastric cancermultiple-instance learningsignet ring cell carcinomatransfer learningweakly-supervised learning

Identifiers

PMID34191660
PMCPMC8258761
OpenAlexW3105799852

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.