Evidence map›Paper›PMID 34191351›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2022

MRI-based synthetic CT shows equivalence to conventional CT for the morphological assessment of the hip joint.

Mateusz C Florkow, Koen Willemsen, Frank Zijlstra, Wouter Foppen, Bart C H van der Wal, Jochem R N van der Voort van Zyp, Max A Viergever, René M Castelein, Harrie Weinans, Marijn van Stralen and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The safety and accuracy of radiation-free spinal navigation using a short, scoliosis-specific BoneMRI-protocol, compared to CT.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  4. Article
  5. Assessment of T2-weighted MRI-derived synthetic CT for the detection of suspected lumbar facet arthritis: a comparative analysis with conventional CT.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Mateusz C FlorkowImage Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0003-2520-7705
Koen WillemsenDepartment of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Frank ZijlstraImage Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
Wouter FoppenDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Bart C H van der WalDepartment of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Jochem R N van der Voort van ZypDivision of Imaging and Oncology, Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Max A ViergeverImage Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
René M CasteleinDepartment of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Harrie WeinansDepartment of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Marijn van StralenImage Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
Ralph J B SakkersDepartment of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Peter R SeevinckImage Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
University Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the accuracy of synthetic computed tomography (sCT), as compared to CT, for the 3D assessment of the hip morphology. Thirty male patients with asymptomatic hips, referred for magnetic resonance (MR) imaging and CT, were included in this retrospective study. sCT images were generated from three-dimensional radiofrequency-spoiled T1-weighted multi-echo gradient-echo MR images using a commercially available deep learning-enabled software and were compared with CT images through mean error and surface distance computation and by means of eight clinical morphometric parameters relevant for hip care. Parameters included center-edge angle (CEA), sharp angle, acetabular index, extrusion index, femoral head center-to-midline distance, acetabular version (AV), and anterior and posterior acetabular sector angles. They were measured by two senior orthopedic surgeons and a radiologist in-training on CT and sCT images. The reliability and agreement of CT- and sCT-based measurements were assessed using intraclass correlation coefficients (ICCs) for absolute agreement, Bland-Altman plots, and two one-sided tests for equivalence. The surface distance between CT- and sCT-based bone models were on average submillimeter. CT- and sCT-based measurements showed moderate to excellent interobserver and intraobserver correlation (0.56 < ICC < 0.99). In particular, the inter/intraobserver agreements were good for AV (ICC > 0.75). For CEA, the intraobserver agreement was good (ICC > 0.75) and the interobserver agreement was moderate (ICC > 0.69). Limits of agreements were similar between intraobserver CT and intermodal measurements. All measurements were found statistically equivalent, with average intermodal differences within the intraobserver limits of agreement. In conclusion, sCT and CT were equivalent for the assessment of the hip joint bone morphology.

Indexed as

Hip JointMagnetic Resonance ImagingHumansMaleReproducibility of ResultsRetrospective StudiesTomography, X-Ray ComputedCTdiagnostic imaginghipMRIsynthetic CT

Identifiers

PMID34191351
PMCPMC9291600
OpenAlexW3173407770

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.