Evidence map›Paper›PMID 34191294›Full record

ReviewPrenatal diagnosis2021

A reasoned approach towards administering COVID-19 vaccines to pregnant women.

Angsumita Pramanick, Abhiram Kanneganti, Jing Lin Jeslyn Wong, Sarah Weiling Li, Pooja Sharma Dimri, Aniza Puteri Mahyuddin, Sailesh Kumar, Sebastian Enrique Illanes, Jerry Kok Yen Chan, Lin Lin Su and 5 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Prenatal diagnosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Pharmacological consideration of COVID-19 infection and vaccines in pregnancy.Journal of the Chinese Medical Association : JCMA · 2022
    Review
  5. The Effect of COVID-19 Endemicity on the Mental Health of Health Workers.Journal of the American Medical Directors Association · 2022
    Article
  6. COVID-19 vaccination during pregnancy.Journal of family medicine and primary care · 2021
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Angsumita PramanickDepartment of Obstetrics and Gynaecology, National University Hospital Singapore, Singapore.ORCID 0000-0002-1544-4945
Abhiram KannegantiDepartment of Obstetrics and Gynaecology, National University Hospital Singapore, Singapore.
Jing Lin Jeslyn WongDepartment of Obstetrics and Gynaecology, National University Hospital Singapore, Singapore.
Sarah Weiling LiDepartment of Obstetrics and Gynaecology, National University Hospital Singapore, Singapore.
Pooja Sharma DimriDepartment of Obstetrics and Gynaecology, National University Hospital Singapore, Singapore.
Aniza Puteri MahyuddinDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0001-8570-8427
Sailesh KumarMater Research Institute-University of Queensland, South Brisbane, Queensland, Australia.
Sebastian Enrique IllanesDepartment of Obstetrics & Gynaecology, Faculty of Medicine, Universidad de los Andes, Santiago, Chile.ORCID 0000-0001-5433-9315
Jerry Kok Yen ChanDepartment of Reproductive Medicine, KK Women's and Children's Hospital, Singapore.
Lin Lin SuDepartment of Obstetrics and Gynaecology, National University Hospital Singapore, Singapore.
Arijit BiswasDepartment of Obstetrics and Gynaecology, National University Hospital Singapore, Singapore.
Paul Anantharajah TambyahInfectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ruby Yun-Ju HuangSchool of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Citra Nurfarah Zaini MattarDepartment of Obstetrics and Gynaecology, National University Hospital Singapore, Singapore.
Mahesh ChoolaniDepartment of Obstetrics and Gynaecology, National University Hospital Singapore, Singapore.ORCID 0000-0001-8336-0973
National University of Singapore · SGNational University Hospital · SGKK Women's and Children's Hospital · SGNational Taiwan University · TWThe University of Queensland · AUUniversidad de Los Andes, Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are over 50 SARS-CoV-2 candidate vaccines undergoing Phase II and III clinical trials. Several vaccines have been approved by regulatory authorities and rolled out for use in different countries. Due to concerns of potential teratogenicity or adverse effect on maternal physiology, pregnancy has been a specific exclusion criterion for most vaccine trials with only two trials not excluding pregnant women. Thus, other than limited animal studies, gradually emerging development and reproductive toxicity data, and observational data from vaccine registries, there is a paucity of reliable information to guide recommendations for the safe vaccination of pregnant women. Pregnancy is a risk factor for severe COVID-19, especially in women with comorbidities, resulting in increased rates of preterm birth and maternal morbidity. We discuss the major SARS-CoV-2 vaccines, their mechanisms of action, efficacy, safety profile and possible benefits to the maternal-fetal dyad to create a rational approach towards maternal vaccination while anticipating and mitigating vaccine-related complications. Pregnant women with high exposure risks or co-morbidities predisposing to severe COVID-19 infection should be prioritised for vaccination. Those with risk factors for adverse effects should be counselled accordingly. It is essential to support patient autonomy by shared decision-making involving a risk-benefit discussion with the pregnant woman.

Indexed as

COVID-19 VaccinesCOVID-19FemaleHumansPregnancyPregnancy Complications, InfectiousSARS-CoV-2VaccinationCOVID-19 Vaccines

Identifiers

PMID34191294
PMCPMC8362094
OpenAlexW3167272325

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.