Evidence map›Paper›PMID 34191258›Full record

ArticleJournal of endocrinological investigation2022

COVID-19 autopsy cases: detection of virus in endocrine tissues.

A M Poma, D Bonuccelli, R Giannini, E Macerola, P Vignali, C Ugolini, L Torregrossa, A Proietti, M Pistello, A Basolo and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Testicular immunity.Molecular aspects of medicine · 2024
    Review
  6. Thyroid dysfunction in COVID-19.Nature reviews. Endocrinology · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Thyroid Autoimmunity and SARS-CoV-2 Infection.Journal of clinical medicine · 2023
    Review
  11. Article
  12. Review
  13. Review
  14. SARS-CoV-2 infection and its effects on the endocrine system.Best practice & research. Clinical endocrinology & metabolism · 2023
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

A M PomaDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
D BonuccelliDepartment of Forensic Medicine, Azienda USL Toscana Nordovest, Lucca, Italy.
R GianniniDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
E MacerolaDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
P VignaliDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
C UgoliniDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
L TorregrossaDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
A ProiettiDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
M PistelloRetrovirus Center and Virology Section, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
A BasoloDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
F SantiniDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
A TonioloGlobal Virus Network, University of Insubria, Varese, Italy.
F BasoloDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy. fulvio.basolo@med.unipi.it.ORCID http://orcid.org/0000-0003-1657-5020
University of Pisa · ITAzienda Usl Toscana Centro · ITUniversity of Insubria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe SARS-CoV-2 genome has been detected in a variety of human samples including blood, urine, semen, and faeces. However, evidence of virus presence in tissues other than lung are limited.

methodsWe investigated whether SARS-CoV-2 could be detected in 50 autoptic specimens of endocrine organs from 29 patients who died of COVID-19.

resultsThe virus was detected in 25 specimens including ten abdominal subcutaneous adipose tissue samples (62%), six testes (67%), and nine thyroid (36%) samples. The analysis of multiple endocrine organ samples obtained from the same patients showed that, in virus-positive cases, the viral genome was consistently detected in all but two matched specimens.

conclusionOur findings show that the virus spread into endocrine organs is a common event in severe cases. Further studies should assess the rate of the phenomenon in clinically mild cases. The potential long-term effects of COVID-19 on endocrine functions should be taken into consideration.

Indexed as

Abdominal FatAdultAutopsyComorbidityCOVID-19Endocrine GlandsFemaleHumansLungMaleMiddle AgedRNA, ViralSARS-CoV-2Subcutaneous FatTestisThyroid GlandRNA, ViralAdipose tissueCOVID-19SARS-CoV-2TestisThyroid

Identifiers

PMID34191258
PMCPMC8243303
OpenAlexW3173515266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.