Evidence map›Paper›PMID 34191238›Full record

ReviewMolecular biology reports2021

The secretome of mesenchymal stem cells and oxidative stress: challenges and opportunities in cell-free regenerative medicine.

Bahareh Rahimi, Mohammad Panahi, Neda Saraygord-Afshari, Neda Taheri, Merve Bilici, Davod Jafari, Effat Alizadeh

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Bahareh Rahimi *Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0002-0208-555X
Mohammad PanahiDepartment of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Neda Saraygord-AfshariDepartment of Medical Biotechnology, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran.
Neda TaheriDepartment of Plant and Animal Biology, University of Esfahan, Esfahan, Iran.ORCID http://orcid.org/0000-0003-3694-5156
Merve BiliciDepartment of Biochemistry, Faculty of Sciences, Ege University, Izmir, Turkey.
Davod JafariDepartment of Medical Biotechnology, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran. Jafari.d@tak.iums.ir.ORCID http://orcid.org/0000-0002-2796-9597
Effat AlizadehDrug Applied Research Center and Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Golgasht Street, 5166/15731, Tabriz, Iran. Alizadehe@tbzmed.ac.ir.ORCID http://orcid.org/0000-0002-7481-0896
Iran University of Medical Sciences · IRTabriz University of Medical Sciences · IREge University · TRUniversity of Isfahan · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last decade, mesenchymal stem cells (MSCs) have been considered a suitable source for cell-based therapy, especially in regenerative medicine. First, the efficacy and functions of MSCs in clinical applications have been attributed to their differentiation ability, called homing and differentiation. However, it has recently been confirmed that MSCs mostly exert their therapeutic effects through soluble paracrine bioactive factors and extracellular vesicles, especially secretome. These secreted components play critical roles in modulating immune responses, improving the survival, and increasing the regeneration of damaged tissues. The secretome content of MSCs is variable under different conditions. Oxidative stress (OS) is one of these conditions that is highly important in MSC therapy and regenerative medicine. High levels of reactive oxygen species (ROS) are produced during isolation, cell culture, and transplantation lead to OS, which induces cell death and apoptosis and limits the efficacy of their regeneration capability. In turn, the preconditioning of MSCs in OS conditions contributes to the secretion of several proteins, cytokines, growth factors, and exosomes, which can improve the antioxidant potential of MSCs against OS. This potential of MSC secretome has turned it into a new promising cell-free tissue regeneration strategy.This review provides a view of MSC secretome under OS conditions, focusing on different secretome contents of MSCs and thier possible therapeutic potential against cell therapy.

Indexed as

Oxidative StressSecretomeAnimalsBiomarkersExosomesExtracellular VesiclesHumansMesenchymal Stem CellsReactive Oxygen SpeciesRegenerationRegenerative MedicineBiomarkersReactive Oxygen SpeciesExosomesMesenchymal stem cellsOxidative stressRegenerative medicineSecretome

Identifiers

PMID34191238
OpenAlexW3176455548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.