Evidence map›Paper›PMID 34191151›Full record

ArticleEuropean journal of hybrid imaging2020

Stefan E Poirier, Benjamin Y M Kwan, Michael T Jurkiewicz, Lina Samargandy, David A Steven, Ana Suller-Marti, Victor Lam Shin Cheung, Ali R Khan, Jonathan Romsa, Frank S Prato and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of hybrid imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Stefan E PoirierLawson Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, Ontario, N6A 4 V2, Canada. spoirie6@uwo.ca.ORCID https://orcid.org/0000-0002-0666-7952
Benjamin Y M KwanDepartment of Diagnostic Radiology, Queen's University, Kingston, Ontario, Canada.
Michael T JurkiewiczDepartment of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Lina SamargandyDepartment of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
David A StevenEpilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Ana Suller-MartiEpilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Victor Lam Shin CheungLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Ali R KhanDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Jonathan RomsaDepartment of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Frank S PratoLawson Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, Ontario, N6A 4 V2, Canada.
Jorge G BurneoEpilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Jonathan D ThiessenLawson Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, Ontario, N6A 4 V2, Canada.
Udunna C AnazodoLawson Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, Ontario, N6A 4 V2, Canada. uanazodo@lawsonimaging.ca.
Western University · CAQueen's University · CASt. Michael's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHybrid PET/MRI can non-invasively improve localization and delineation of the epileptic focus (EF) prior to surgical resection in medically refractory epilepsy (MRE), especially when MRI is negative or equivocal. In this study, we developed a PET-guided diffusion tractography (PET/DTI) approach combining

methodsFDG-PET and diffusion MRI of 14 MRI-negative or equivocal MRE patients were used to retrospectively pilot the PET/DTI approach. We used asymmetry index (AI) mapping of FDG-PET to detect the EF as brain areas showing the largest decrease in FDG uptake between hemispheres. Seed-based WM fiber tracking was performed on DTI images with a seed location in WM 3 mm from the EF. Fiber tractography was repeated in the contralateral brain region (opposite to EF), which served as a control for this study. WM fibers were quantified by calculating the fiber count, mean fractional anisotropy (FA), mean fiber length, and mean cross-section of each fiber bundle. WM integrity was assessed through fiber visualization and by normalizing ipsilateral fiber measurements to contralateral fiber measurements. The added value of PET/DTI in clinical decision-making was evaluated by a senior neurologist.

resultsIn over 60% of the patient cohort, AI mapping findings were concordant with clinical reports on seizure-onset localization and lateralization. Mean FA, fiber count, and mean fiber length were decreased in 14/14 (100%), 13/14 (93%), and 12/14 (86%) patients, respectively. PET/DTI improved diagnostic confidence in 10/14 (71%) patients and indicated that surgical candidacy be reassessed in 3/6 (50%) patients who had not undergone surgery.

conclusionsWe demonstrate here the utility of AI mapping in detecting the EF based on brain regions showing decreased FDG-PET activity and, when coupled with DTI, could be a powerful tool for detecting EF and assessing WM integrity in MRI-negative epilepsy. PET/DTI could be used to further enhance clinical decision-making in epilepsy surgery.

Indexed as

Asymmetry indexDiffusion tractographyFluorodeoxyglucoseMedically refractory epilepsyPET/MRI

Identifiers

PMID34191151
PMCPMC8218143
OpenAlexW3037018865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.