Evidence map›Paper›PMID 34191125›Full record

ArticleJournal of bone and mineral metabolism2021

6-Shogaol promotes bone resorption and accelerates orthodontic tooth movement through the JNK-NFATc1 signaling axis.

Xiaofang Zhu, Hao Yuan, Ouyang Ningjuan, Carroll Ann Trotman, Thomas E Van Dyke, Jake Jinkun Chen, Guofang Shen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Research progress in periodontally accelerated osteogenic orthodontics.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Review
  3. Review
  4. Review
  5. Core scientific issues of orthodontic tooth movement: position objective, efficiency, and accuracy.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xiaofang ZhuDepartment of Oral and Cranio-Maxillofacial Surgery, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hao YuanDepartment of Oral and Cranio-Maxillofacial Surgery, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ouyang NingjuanDepartment of Oral and Cranio-Maxillofacial Surgery, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Carroll Ann TrotmanDepartment of Orthodontics, Tufts University School of Dental Medicine, Boston, MA, USA.
Thomas E Van DykeThe Forsyth Institute, Cambridge, MA, USA.
Jake Jinkun ChenDivision of Oral Biology, Tufts University School of Dental Medicine, Boston, MA, USA. jk.chen@tufts.edu.
Guofang ShenDepartment of Oral and Cranio-Maxillofacial Surgery, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. shengf@sumhs.edu.cn.
Shanghai Ninth People's Hospital · CNTufts University · US

Funding

Mechanisms of Resolvin E1 in Periodontal RegenerationR01DE025020 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI VAN DYKE, THOMAS ELLIOTT · 2015 to 2023
$4.9M
Roles of Noncoding RNA in Bone RegenerationR01DE025681 · NIDCR · TUFTS UNIVERSITY BOSTON · PI CHEN, JAKE JINKUN · 2016 to 2024
$4.5M
A Long Noncoding RNA Amerliorates Periodontitis via Distinct Epigenetic PathwaysR01DE030074 · NIDCR · TUFTS UNIVERSITY BOSTON · PI CHEN, JAKE JINKUN · 2021 to 2025
$3.5M
Targeting Surgeons Decision-Making for Lip SurgeryU01DE024503 · NIDCR · TUFTS UNIVERSITY BOSTON · PI TROTMAN, CARROLL ANN · 2015 to 2020
$2.3M
Potentials of Epigenetic Molecules in Attenuating the Phenotypes of PeriodontitisR01DE032006 · NIDCR · TUFTS UNIVERSITY BOSTON · PI JAKE JINKUN CHEN · 2023 to 2026
$2.0M
Alveolar Bone Regeneration in Diabetic PeriodontitisR01DE026507 · NIDCR · TUFTS UNIVERSITY BOSTON · PI CHEN, JAKE JINKUN · 2017 to 2021
$2.0M
Therapeutic Strategies for Treating Type 2 Diabetes Mellitus -Associated PeriodonR01DE021464 · NIDCR · TUFTS UNIVERSITY BOSTON · PI CHEN, JAKE JINKUN · 2011 to 2013
$1.3M
NIDCR NIH HHS R01 DE021464NIDCR NIH HHS R01 DE025020NIDCR NIH HHS R01 DE025681NIDCR NIH HHS R01 DE026507NIDCR NIH HHS R01 DE030074NIDCR NIH HHS R01 DE032006NIDCR NIH HHS U01 DE024503NIH HHS R01 DE025020NIH HHS R01 DE21464NIH HHS R01 DE25681NIH HHS R01 DE26507NIH HHS U01 DE024503
6 · The paper itself

Abstract

introductionCorticotomy is widely used in clinical practice to accelerate tooth movement and shorten the duration of orthodontic treatment. It is effective, but an invasive surgery is needed to induce alveolar bone osteopenia that enable rapid tooth movement. In this study, we discovered the potential of 6-shogaol as a more patient-friendly non-invasive alternative to induce transient osteopenia and accelerate tooth movement. MATERIALS AND

methodsThe effects of 6-shogaol on the bone marrow macrophages (BMM) proliferation and osteoclast differentiation, and bone resorption were determined in vitro. Sprague-Dawley rats were distributed into three groups: CON, IPinj or Localinj and euthanized at day 28. Micro-CT, histology, immunohistological, and TUNEL analysis were performed to evaluate the tooth movement acceleration effect of 6-shogaol.

resultsIn vitro, 6-shogaol promotes osteoclast differentiation and functional demineralization of alveolar bone. RANKL-induced mRNA expression of osteoclastic-specific genes was significantly higher in the presence of 6-shogaol. A dose-dependent increase in the area of TRAP-positive cells was observed with 6-shogaol treatment. F-actin ring formation and increased bone resorption confirmed that osteoclasts treated with 6-shogaol were mature and functional. 6-shogaol stimulated JNK activation and NFATc1 expression during osteoclast differentiation. In vivo, 6-shogaol promotes alveolar bone transient osteopenia and accelerates orthodontic tooth movement. Alveolar bone mass was reduced, more osteoclasts were observed in bone resorption lacunae on the compression side, and the expression of RANKL and sclerostin were higher than the control group. In conclusion, our results suggest that 6-shogoal accelerates tooth movement by inducing osteopenia by a mechanism similar to surgically induced bone injury.

Indexed as

Bone ResorptionTooth Movement TechniquesAnimalsCatecholsHumansNFATC Transcription FactorsOsteoclastsRatsRats, Sprague-DawleyCatecholsNFATC1 protein, humanNFATC Transcription Factorsshogaol6-ShogaolOsteoclastsOsteopeniaTooth movement

Identifiers

PMID34191125
PMCPMC8595588
OpenAlexW3175079460

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.