Evidence map›Paper›PMID 34191100›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Prognostic value of regional myocardial flow reserve derived from

Elia von Felten, Dominik C Benz, Georgios Benetos, Jessica Baehler, Dimitri Patriki, Georgios P Rampidis, Andreas A Giannopoulos, Adam Bakula, Christoph Gräni, Aju P Pazhenkottil and 4 more

Abstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Diagnosis of multivessel coronary artery disease usingJapanese journal of radiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elia von FeltenDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Dominik C BenzDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Georgios BenetosDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Jessica BaehlerDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Dimitri PatrikiDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Georgios P RampidisDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Andreas A GiannopoulosDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Adam BakulaDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Christoph GräniDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Aju P PazhenkottilDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Catherine GebhardDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Tobias A FuchsDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Philipp A KaufmannDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland.
Ronny R BuechelDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Ramistr. 100, CH-8091, Zurich, Switzerland. ronny.buechel@usz.ch.ORCID http://orcid.org/0000-0001-8064-8904

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the prognostic value of regional quantitative myocardial flow measures as assessed by

methodsWe retrospectively included 150 consecutive patients with suspected CAD who underwent clinically indicated 13 N-ammonia PET-MPI and who did not undergo revascularization within 90 days of PET-MPI. The presence or absence of a decreased global myocardial flow reserve (i.e., MFR < 2) as well as decreased regional MFR (i.e., ≥ 2 adjacent segments with MFR < 2) was recorded, and patients were classified as having preserved global and regional MFR (MFR group 1), preserved global but decreased regional MFR (MFR group 2), or decreased global and regional MFR (MFR group 3). We obtained follow-up regarding major adverse cardiac events (MACE, i.e., a combined endpoint including all-cause death, non-fatal myocardial infarction, and late revascularization) and all-cause death.

resultsOver a median follow-up of 50 months (IQR 38-103), 30 events occurred in 29 patients. Kaplan-Meier analysis showed significantly reduced event-free and overall survival in MFR groups 2 and 3 compared to MFR group 1 (log-rank: p = 0.015 and p = 0.013). In a multivariable Cox regression analysis, decreased regional MFR was an independent predictor for MACE (adjusted HR 3.44, 95% CI 1.17-10.11, p = 0.024) and all-cause death (adjusted HR 4.72, 95% CI 1.07-20.7, p = 0.04).

conclusionsA decreased regional MFR as assessed by 13 N-ammonia PET-MPI confers prognostic value by identifying patients at increased risk for future adverse cardiac outcomes and all-cause death.

Indexed as

Coronary Artery DiseaseMyocardial Perfusion ImagingAmmoniaHumansPositron-Emission TomographyPrognosisRetrospective StudiesAmmoniaCoronary artery diseaseMyocardial blood flowMyocardial flow reservePositron emission tomography

Identifiers

PMID34191100
PMCPMC8712296

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.