Evidence map›Paper›PMID 34191077›Full record

ArticleArchives of toxicology2021

Orphan nuclear receptor ERRγ regulates hepatic TGF-β2 expression and fibrogenic response in CCl

Yoon Seok Jung, Yong-Hoon Kim, Kamalakannan Radhakrishnan, Jina Kim, In-Kyu Lee, Sung Jin Cho, Don-Kyu Kim, Steven Dooley, Chul-Ho Lee, Hueng-Sik Choi

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Yoon Seok JungSchool of Biological Sciences and Technology, Chonnam National University, Gwangju, 61186, Republic of Korea.
Yong-Hoon Kim *Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
Kamalakannan RadhakrishnanSchool of Biological Sciences and Technology, Chonnam National University, Gwangju, 61186, Republic of Korea.
Jina KimDaegu-Gyeongbuk Medical Innovation Foundation, New Drug Development Center, Daegu, 41061, Republic of Korea.
In-Kyu LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.
Sung Jin ChoDaegu-Gyeongbuk Medical Innovation Foundation, New Drug Development Center, Daegu, 41061, Republic of Korea.
Don-Kyu KimDepartment of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju, 61186, Republic of Korea.
Steven DooleyDepartment of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Chul-Ho LeeLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. chullee@kribb.re.kr.ORCID http://orcid.org/0000-0002-6996-5746
Hueng-Sik ChoiSchool of Biological Sciences and Technology, Chonnam National University, Gwangju, 61186, Republic of Korea. hsc@chonnam.ac.kr.ORCID http://orcid.org/0000-0002-3163-1572
Chonnam National University · KRKorea Research Institute of Bioscience and Biotechnology · KRDaegu-Gyeongbuk Medical Innovation Foundation · KRHeidelberg University · DEKyungpook National University · KRKyungpook National University Hospital · KR

Funding

Korea Health Industry Development Institute HI16C1501National Creative Research Initiatives Grant 20110018305National Research Foundation of Korea NRF-2019R1C1C1005319National Research Foundation of Korea NRF-2020R1A2C3006952National Research Foundation of Korea NRF-2020R1A6A3A01096145National Research Foundation of Korea NRF-2021R1A2C3004923Stiftung für Biomedizinische Alkoholforschung PTJ-031L0043
6 · The paper itself

Abstract

Acute liver injury results from the complex interactions of various pathological processes. The TGF-β superfamily plays a crucial role in orchestrating fibrogenic response. In contrast to TGF-β1, a role of TGF-β2 in hepatic fibrogenic response has not been fully investigated. In this study, we showed that TGF-β2 gene expression and secretion are induced in the liver of CCl

Indexed as

AnimalsCarbon TetrachlorideCell LineDisease Models, AnimalGene Expression RegulationGene Knockout TechniquesHEK293 CellsHepatocytesHumansLiver DiseasesMaleMiceMice, Inbred C57BLReceptors, EstrogenTamoxifenTransforming Growth Factor beta2Carbon TetrachlorideEsrrg protein, mouseGSK5182Receptors, EstrogenTamoxifenTgfb2 protein, mouseTransforming Growth Factor beta2CCl4ERRγGSK5182IL6TGF-β2

Identifiers

PMID34191077
OpenAlexW3175960294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.