Evidence map›Paper›PMID 34191065›Full record

ArticleActa neurochirurgica. Supplement2021

Redistributing Central Target Dose Hot Spots for Hypofractionated Radiosurgery of Large Brain Tumors: A Proof-of-Principle Study.

Lijun Ma, Steve E Braunstein, Encouse Golden, Shannon Fogh, Jean Nakamura, Michael W McDermott, Penny K Sneed

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Article in Acta neurochirurgica. Supplement, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lijun MaDepartment of Radiation Oncology, University of California San Francisco (UCSF), San Francisco, CA, USA. lijun.ma@ucsf.edu.
Steve E BraunsteinDepartment of Radiation Oncology, University of California San Francisco (UCSF), San Francisco, CA, USA.
Encouse GoldenDepartment of Radiation Oncology, University of California San Francisco (UCSF), San Francisco, CA, USA.
Shannon FoghDepartment of Radiation Oncology, University of California San Francisco (UCSF), San Francisco, CA, USA.
Jean NakamuraDepartment of Radiation Oncology, University of California San Francisco (UCSF), San Francisco, CA, USA.
Michael W McDermottDepartment of Neurosurgery, University of California San Francisco (UCSF), San Francisco, CA, USA.
Penny K SneedDepartment of Radiation Oncology, University of California San Francisco (UCSF), San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe present proof-of-principle study investigated radiobiological effects of redistributing central target dose hot spots across different treatment fractions during hypofractionated stereotactic radiosurgery (HSRS) of large intracranial tumors.

methodsRedistribution of central target dose hot spots during HSRS was simulated, and its effects were evaluated in eight cases of brain metastases. To assess dose variations in the target across N number of treatment fractions, a generalized biologically effective dose (gBED) was formulated. The gBED enhancement ratio was defined as the ratio of gBED in the tested treatment plan (with central target dose hot spot redistributions across fractions) to gBED in the conventional treatment plan (without central target dose hot spot redistributions).

resultsAt a median α value of 0.3/Gy, the tested treatment plans resulted in average gBED increases of 15.6 ± 3.5% and 8.3 ± 1.8% for α/β ratios of 2 and 10 Gy, respectively. In comparison with conventional treatment plans, the differences in the Paddick conformity index and gradient index did not exceed 2%.

conclusionRedistributing central target dose hot spots across different treatment fractions during HSRS may be considered promising for enhancing gBED in the target. It may be beneficial for management of large intracranial neoplasms; thus, it warrants further clinical testing.

Indexed as

Brain NeoplasmsRadiosurgeryHumansBiologically effective doseBiological modelingHypofractionated stereotactic radiosurgeryIntracranial metastasesTargetingTreatment planning

Identifiers

PMID34191065

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.