Evidence map›Paper›PMID 34190643›Full record

ArticleDiabetes & vascular disease research

Roles of vascular endothelial and smooth muscle cells in the vasculoprotective effect of insulin in a mouse model of restenosis.

Yusaku Mori, Marel Gonzalez Medina, Zhiwei Liu, June Guo, Luke S Dingwell, Simon Chiang, Carl Ronald Kahn, Mansoor Husain, Adria Giacca

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes & vascular disease research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Yusaku MoriDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Marel Gonzalez MedinaDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Zhiwei LiuDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
June GuoDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Luke S DingwellInstitute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Simon ChiangDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Carl Ronald KahnJoslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Mansoor HusainDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Adria GiaccaDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
University of Toronto · CADiabetes Canada · CAJoslin Diabetes Center · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
INSULIN RECEPTOR STRUCTURE AND TURNOVERR37DK031036 · NIDDK · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 2000 to 2019
$12.9M
The Insulin Receptor and Its Signaling MechanismsR01DK031036 · NIDDK · JOSLIN DIABETES CENTER · PI C RONALD KAHN · 1986 to 2026
$4.2M
NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK031036NIDDK NIH HHS R37 DK031036
6 · The paper itself

Abstract

backgroundInsulin exerts vasculoprotective effects on endothelial cells (ECs) and growth-promoting effects on vascular smooth muscle cells (SMCs) in vitro, and suppresses neointimal growth in vivo. Here we determined the role of ECs and SMCs in the effect of insulin on neointimal growth.

methodsMice with transgene CreER

resultsTamoxifen-treated

conclusionInsulin action in both ECs and SMCs is required for the "anti-restenotic" effect of insulin in vivo.

Indexed as

NeointimaAnimalsDisease Models, AnimalDrug ImplantsEndothelial CellsEndothelium, VascularFemoral ArteryHypoglycemic AgentsInsulinMaleMiceMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleReceptor, InsulinVascular System InjuriesDrug ImplantsHypoglycemic AgentsInsulinReceptor, InsulinInsulinmouseneointimavascular endothelial cellvascular smooth muscle cell

Identifiers

PMID34190643
PMCPMC8482728
OpenAlexW3174943619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.