Evidence map›Paper›PMID 34190610›Full record

ReviewApplied and environmental microbiology2021

Forty Years of Oxalobacter formigenes, a Gutsy Oxalate-Degrading Specialist.

Steven L Daniel, Luke Moradi, Henry Paiste, Kyle D Wood, Dean G Assimos, Ross P Holmes, Lama Nazzal, Marguerite Hatch, John Knight

Open access · greenAbstract readReview
In one paragraph

Review in Applied and environmental microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Gut microbes · 2025
    Article
  11. Article
  12. Role of UropathogenicPathogens (Basel, Switzerland) · 2025
    Review
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Colonization withbioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. InducingKidney international reports · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Steven L DanielDepartment of Biological Sciences, Eastern Illinois Universitygrid.255392.a, Charleston, Illinois, USA.
Luke MoradiSchool of Medicine, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Henry PaisteSchool of Medicine, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Kyle D WoodDepartment of Urology, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Dean G AssimosDepartment of Urology, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Ross P HolmesDepartment of Urology, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Lama NazzalDepartment of Medicine, NYU Grossman School of Medicine, New York, New York, USA.
Marguerite HatchDepartment of Pathology, Immunology & Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.
John KnightDepartment of Urology, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
University of Alabama at Birmingham · USEastern Illinois University · USNew York University · USUniversity of Florida · US

Funding

Oxalobacter formigenes colonization and oxalate excretion in calcium oxalate kidney stone diseaseR01DK087967 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KNIGHT, JOHN · 2011 to 2020
$3.5M
Dietary Oxalate and Kidney Stone FormationR01DK062284 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ASSIMOS, DEAN GEORGE · 2002 to 2010
$2.4M
The Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone FormersP20DK119788 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ASSIMOS, DEAN GEORGE · 2018 to 2021
$1.2M
Obesity and Endogenous Oxalate SynthesisK08DK115833 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WOOD, KYLE D · 2018 to 2022
$960k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK-62284NIDDK NIH HHS K08 DK115833NIDDK NIH HHS P20 DK119788NIDDK NIH HHS R01 DK062284NIDDK NIH HHS R01 DK087967
6 · The paper itself

Abstract

Oxalobacter formigenes, a unique anaerobic bacterium that relies solely on oxalate for growth, is a key oxalate-degrading bacterium in the mammalian intestinal tract. Degradation of oxalate in the gut by

Indexed as

Oxalobacter formigenesAnimalsGastrointestinal MicrobiomeGenomicsHumansInactivation, MetabolicMetabolomicsNephrolithiasisOxalatesOxalatesculture methodsgut microbiomekidney stone diseaseoxalate degradationOxalobacter formigenesprobiotics

Identifiers

PMID34190610
PMCPMC8388816
OpenAlexW3177405100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.