Evidence map›Paper›PMID 34190577›Full record

ArticleCirculation. Heart failure2021

Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit.

Sunil Jit R J Logantha, Xue J Cai, Joseph Yanni, Caroline B Jones, Robert S Stephenson, Luke Stuart, Gillian Quigley, Oliver Monfredi, Shu Nakao, Il-Young Oh and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 13 institutions in 5 countries.

Sunil Jit R J Logantha *Division of Cardiovascular Sciences (S.J.R.J.L., X.J.C., J.Y., L.S., G.Q., S.N., I.-Y.O., A.K., A.V., H.D., M.R.B., G.H.), University of Manchester, United Kingdom.
Xue J Cai *Division of Cardiovascular Sciences (S.J.R.J.L., X.J.C., J.Y., L.S., G.Q., S.N., I.-Y.O., A.K., A.V., H.D., M.R.B., G.H.), University of Manchester, United Kingdom.
Joseph Yanni *Division of Cardiovascular Sciences (S.J.R.J.L., X.J.C., J.Y., L.S., G.Q., S.N., I.-Y.O., A.K., A.V., H.D., M.R.B., G.H.), University of Manchester, United Kingdom.
Caroline B JonesAlder Hey Children's National Health Service Foundation Trust, Liverpool, United Kingdom (C.B.J.).
Robert S StephensonSchool of Sport and Exercise Sciences, Liverpool John Moores University, United Kingdom (R.S.S., J.C.J.).
Luke StuartDivision of Cardiovascular Sciences (S.J.R.J.L., X.J.C., J.Y., L.S., G.Q., S.N., I.-Y.O., A.K., A.V., H.D., M.R.B., G.H.), University of Manchester, United Kingdom.
Gillian QuigleyDivision of Cardiovascular Sciences (S.J.R.J.L., X.J.C., J.Y., L.S., G.Q., S.N., I.-Y.O., A.K., A.V., H.D., M.R.B., G.H.), University of Manchester, United Kingdom.
Oliver MonfrediDivision of Cardiovascular Medicine, University of Virginia, Charlottesville (O.M.).
Shu NakaoDivision of Cardiovascular Sciences (S.J.R.J.L., X.J.C., J.Y., L.S., G.Q., S.N., I.-Y.O., A.K., A.V., H.D., M.R.B., G.H.), University of Manchester, United Kingdom.
Il-Young OhDivision of Cardiovascular Sciences (S.J.R.J.L., X.J.C., J.Y., L.S., G.Q., S.N., I.-Y.O., A.K., A.V., H.D., M.R.B., G.H.), University of Manchester, United Kingdom.
Tobias StarborgWellcome Centre for Cell Matrix Research (T.S.), University of Manchester, United Kingdom.
Ashraf KitmittoDivision of Cardiovascular Sciences (S.J.R.J.L., X.J.C., J.Y., L.S., G.Q., S.N., I.-Y.O., A.K., A.V., H.D., M.R.B., G.H.), University of Manchester, United Kingdom.
Akbar VohraDivision of Cardiovascular Sciences (S.J.R.J.L., X.J.C., J.Y., L.S., G.Q., S.N., I.-Y.O., A.K., A.V., H.D., M.R.B., G.H.), University of Manchester, United Kingdom.
Robert C HutcheonDivision of Clinical Sciences (R.C.H.), University of Liverpool, United Kingdom.
Antonio F CornoMemorial Hermann Children's Hospital, University of Texas Health, Houston (A.F.C.).
Jonathan C JarvisSchool of Sport and Exercise Sciences, Liverpool John Moores University, United Kingdom (R.S.S., J.C.J.).
Halina DobrzynskiDivision of Cardiovascular Sciences (S.J.R.J.L., X.J.C., J.Y., L.S., G.Q., S.N., I.-Y.O., A.K., A.V., H.D., M.R.B., G.H.), University of Manchester, United Kingdom.
Mark R Boyett *Division of Cardiovascular Sciences (S.J.R.J.L., X.J.C., J.Y., L.S., G.Q., S.N., I.-Y.O., A.K., A.V., H.D., M.R.B., G.H.), University of Manchester, United Kingdom.
George Hart *Division of Cardiovascular Sciences (S.J.R.J.L., X.J.C., J.Y., L.S., G.Q., S.N., I.-Y.O., A.K., A.V., H.D., M.R.B., G.H.), University of Manchester, United Kingdom.
Jisc · GBLiverpool John Moores University · GBUniversity of Liverpool · GBAlder Hey Children's NHS Foundation Trust · GBJacobson Holman (United States) · USJagiellonian University · PLManchester University NHS Foundation Trust · GBMemorial Hermann · USNational Institute on Aging · USRCA (United States) · USRitsumeikan University · JPSeoul National University Bundang Hospital · KRWellcome Centre for Cell-Matrix Research · GB

Funding

British Heart Foundation PG/15/16/31330British Heart Foundation RG/11/18/29257
6 · The paper itself

Abstract

backgroundPurkinje fibers (PFs) control timing of ventricular conduction and play a key role in arrhythmogenesis in heart failure (HF) patients. We investigated the effects of HF on PFs.

methodsEchocardiography, electrocardiography, micro-computed tomography, quantitative polymerase chain reaction, immunohistochemistry, volume electron microscopy, and sharp microelectrode electrophysiology were used.

resultsCongestive HF was induced in rabbits by left ventricular volume- and pressure-overload producing left ventricular hypertrophy, diminished fractional shortening and ejection fraction, and increased left ventricular dimensions. HF baseline QRS and corrected QT interval were prolonged by 17% and 21% (mean±SEMs: 303±6 ms HF, 249±11 ms control; n=8/7;

conclusionsSevere volume- followed by pressure-overload causes rapidly progressing HF with extensive remodeling of PFs. The PF network is central to both arrhythmogenesis and contractile dysfunction and the pathological remodeling may increase the risk of fatal arrhythmias in HF patients.

Indexed as

Action PotentialsAnimalsCardiac Pacing, ArtificialElectrocardiographyHeart FailureHeart RateHeart VentriclesMaleModels, AnimalRabbitsVentricular RemodelingX-Ray Microtomographyelectron microscopyheart failureion channelsPurkinje fibersrabbitstomography

Identifiers

PMID34190577
PMCPMC8288482
OpenAlexW3175249226

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.