Evidence map›Paper›PMID 34190542›Full record

ArticleJournal of the American Chemical Society2021

Py-Macrodipa: A Janus Chelator Capable of Binding Medicinally Relevant Rare-Earth Radiometals of Disparate Sizes.

Aohan Hu, Eduardo Aluicio-Sarduy, Victoria Brown, Samantha N MacMillan, Kaelyn V Becker, Todd E Barnhart, Valery Radchenko, Caterina F Ramogida, Jonathan W Engle, Justin J Wilson

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Hydroxyquinoline-functionalised aza-crown macrocycles for lanthanide coordination.Dalton transactions (Cambridge, England : 2003) · 2026
    Article
  7. Article
  8. DFT calculation of AcScientific reports · 2026
    Article
  9. Article
  10. Article
  11. Chelation of [Dalton transactions (Cambridge, England : 2003) · 2024
    Article
  12. Complexation of 3p-Heliyon · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Targeted Alpha Therapy: All We Need to Know aboutPharmaceuticals (Basel, Switzerland) · 2023
    Review
  17. Steric Effects on the Chelation of MnChemistry (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  18. Evaluation ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  19. Radiolabeling andRSC chemical biology · 2023
    Article
  20. Pharmaceutics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aohan HuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0002-9720-3159
Eduardo Aluicio-SarduyDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Victoria BrownDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.ORCID 0000-0002-0216-3538
Samantha N MacMillanDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0001-6516-1823
Kaelyn V BeckerDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Todd E BarnhartDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Valery RadchenkoLife Sciences Division, TRIUMF, Vancouver, British Columbia V6T 2A3, Canada.
Caterina F RamogidaDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.ORCID 0000-0003-4815-2647
Jonathan W EngleDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-3399-7228
Justin J WilsonDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0002-4086-7982

Funding

Chelation strategies for s-, p-, and f-block radionuclides for targeted alpha therapyR01EB029259 · NIBIB · CORNELL UNIVERSITY · PI WILSON, JUSTIN J · 2020 to 2023
$1.4M
Expanding the Therapeutic Potential of the Alpha Emitter Radium-223R21EB027282 · NIBIB · CORNELL UNIVERSITY · PI WILSON, JUSTIN J · 2019 to 2021
$619k
NIBIB NIH HHS R01 EB029259NIBIB NIH HHS R21 EB027282
6 · The paper itself

Abstract

Nuclear medicine leverages different types of radiometals for disease diagnosis and treatment, but these applications usually require them to be stably chelated. Given the often-disparate chemical properties of these radionuclides, it is challenging to find a single chelator that binds all of them effectively. Toward addressing this problem, we recently reported a macrocyclic chelator macrodipa with an unprecedented "dual-size-selectivity" pattern for lanthanide (Ln

Indexed as

Chelating AgentsDrug Delivery SystemsDrug DesignHydrogen BondingLanthanoid Series ElementsMacrocyclic CompoundsModels, MolecularMolecular StructurePyridinesChelating AgentsLanthanoid Series ElementsMacrocyclic CompoundsPy-macrodipaPyridines

Identifiers

PMID34190542
PMCPMC8491276

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.