Evidence map›Paper›PMID 34190428›Full record

ArticleESC heart failure2021

Reaching consensus for unified medical language in Fontan care.

Tarek Alsaied, Rahul H Rathod, Jamil A Aboulhosn, Werner Budts, Jeffrey B Anderson, Helmut Baumgartner, David W Brown, Rachael Cordina, Yves D'udekem, Salil Ginde and 10 more

Open access · goldAbstract readConsensus Statement
In one paragraph

Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Changes in pharmacotherapy in adults with Fontan circulation and associations with outcomes.International journal of cardiology. Congenital heart disease · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Fontan-Associated Liver Disease.Seminars in liver disease · 2025
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 15 institutions in 6 countries.

Tarek AlsaiedHeart Institute, Department of Pediatrics, Pittsburgh Children's Hospital Medical Center, Pittsburgh, PA, USA.ORCID 0000-0002-3777-4822
Rahul H RathodDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Jamil A AboulhosnAhmanson/UCLA Adult Congenital Heart Disease Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0002-0209-9505
Werner BudtsDivision of Congenital and Structural Cardiology, University Hospitals Leuven, Leuven, Belgium.
Jeffrey B AndersonHeart Institute, Department of Pediatrics, Pittsburgh Children's Hospital Medical Center, Pittsburgh, PA, USA.
Helmut BaumgartnerDepartment of Cardiology: Adult Congenital and Valvular Heart Disease, University Hospital Muenster, Muenster, Germany.
David W BrownDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Rachael CordinaAdult Congenital Heart Disease Service and Pulmonary Hypertension Service, Royal Prince Alfred Hospital, Sydney, Australia.
Yves D'udekemDepartment of Cardiac Surgery and Children's National Heart Institute, Children's National Hospital, Washington, DC, USA.ORCID 0000-0003-1851-7836
Salil GindeDivision of Pediatric Cardiology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0001-9218-1993
David J GoldbergDivision of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Bryan H GoldsteinHeart Institute, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-8508-9523
Adam M LubertHeart Institute, Department of Pediatrics, Pittsburgh Children's Hospital Medical Center, Pittsburgh, PA, USA.ORCID 0000-0001-6401-9980
Erwin OechslinCongenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Toronto, Canada.ORCID 0000-0001-7084-8494
Alexander R OpotowskyHeart Institute, Department of Pediatrics, Pittsburgh Children's Hospital Medical Center, Pittsburgh, PA, USA.ORCID 0000-0002-6107-2281
Jack RychikDivision of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Kurt R SchumacherCongenital Heart Center, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
Anne Marie ValenteDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Gail WrightDivision of Cardiology, Department of Pediatrics, Stanford University School of Medicine, Santa Clara, CA, USA.ORCID 0000-0002-0756-3805
Gruschen R VeldtmanAdult Congenital Heart Disease Service, Heart Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Boston Children's Hospital · USChildren's Hospital of Pittsburgh · USChildren's Hospital of Philadelphia · USChildren's National · USCincinnati Children's Hospital Medical Center · USKing Faisal Specialist Hospital & Research Centre · SAKU Leuven · BEMedical College of Wisconsin · USRoyal Prince Alfred Hospital · AUSanta Clara University · USUniversity Health Network · CAUniversity Hospital Münster · DEUniversity of California, Los Angeles · USUniversity of Michigan · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe Fontan operation has resulted in improved survival in patients with single-ventricle congenital heart disease. As a result, there is a growing population of teenagers and adults with a Fontan circulation. Many co-morbidities have been increasingly recognized in this population due to the unique features of the Fontan circulation. Standardization of how Fontan co-morbid conditions are defined will help facilitate understanding, consistency and interpretability of research and clinical experience. Unifying common language usage in Fontan is a critical precursor step for data comparison of research findings and clinical outcomes and ultimately accelerating improvements in management for this growing group of patients. This manuscript aimed to create unified definitions for morbidities seen after the Fontan palliation.

methodsIn association of many congenital heart disease organizations, this work used Delphi methodology to reach a broad consensus among recognized experts regarding commonly used terms in Fontan care and research. Each definition underwent at least three rounds of revisions to reach a final definition through surveys sent to experts in the field of single-ventricle care.

resultsThe process of reaching a consensus on multiple morbidities associated with the Fontan procedure is summarized in this manuscript. The different versions that preceded reaching the consensus are also presented in the Supporting Information. Table 1 represents the final definitions according to the consensus.

conclusionsWe propose the use of these definitions for clinical care, future research studies, registry development and clinical trials.

Indexed as

Fontan ProcedureHeart Defects, CongenitalAdolescentAdultHumansLanguageRegistriesCirrhosisCongenital heart diseaseConsensusFontanPortal hypertensionSingle ventricle

Identifiers

PMID34190428
PMCPMC8497335
OpenAlexW3177479933

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.