Evidence map›Paper›PMID 34190042›Full record

ArticleeLife2021

Miro1-dependent mitochondrial dynamics in parvalbumin interneurons.

Georgina Kontou, Pantelis Antonoudiou, Marina Podpolny, Blanka R Szulc, I Lorena Arancibia-Carcamo, Nathalie F Higgs, Guillermo Lopez-Domenech, Patricia C Salinas, Edward O Mann, Josef T Kittler

Open access · greenAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 citations in OpenAlex.

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  14. Parvalbumin interneuron deficits in schizophrenia.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Georgina KontouDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.ORCID 0000-0002-0551-1577
Pantelis AntonoudiouDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Marina PodpolnyDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.
Blanka R SzulcDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
I Lorena Arancibia-CarcamoDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.ORCID 0000-0002-0624-3850
Nathalie F HiggsDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
Guillermo Lopez-DomenechDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.ORCID 0000-0002-3114-2082
Patricia C SalinasDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.ORCID 0000-0002-5748-083X
Edward O MannDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-2468-7148
Josef T KittlerDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.ORCID 0000-0002-3437-9456
University College London · GBUniversity of Oxford · GB

Funding

European Research Council 282430Medical Research Council 1405150Medical Research Council MR/M024083/1
6 · The paper itself

Abstract

The spatiotemporal distribution of mitochondria is crucial for precise ATP provision and calcium buffering required to support neuronal signaling. Fast-spiking GABAergic interneurons expressing parvalbumin (PV+) have a high mitochondrial content reflecting their large energy utilization. The importance for correct trafficking and precise mitochondrial positioning remains poorly elucidated in inhibitory neurons. Miro1 is a Ca²

Indexed as

AnimalsAnimals, NewbornBehavior, AnimalFemaleGenotypeHippocampusInterneuronsMaleMiceMice, KnockoutMice, TransgenicMitochondriaParvalbuminsrho GTP-Binding ProteinsMiro-1 protein, mouseParvalbuminsrho GTP-Binding Proteinscell biologygamma oscillationsmitochondrial traffickingmouseneuroscienceparvalbumin interneurons

Identifiers

PMID34190042
PMCPMC8294849
OpenAlexW2903263898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.