Evidence map›Paper›PMID 34190031›Full record

ArticlemAbs

A T cell redirection platform for co-targeting dual antigens on solid tumors.

Leonie Enderle, Karim H Shalaby, Maryna Gorelik, Alexander Weiss, Levi L Blazer, Marcin Paduch, Lia Cardarelli, Anthony Kossiakoff, Jarrett J Adams, Sachdev S Sidhu

Open access · goldAbstract read
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Leonie EnderleDonnelly Centre, University of Toronto, Toronto, Canada.
Karim H ShalabyDonnelly Centre, University of Toronto, Toronto, Canada.
Maryna GorelikDonnelly Centre, University of Toronto, Toronto, Canada.
Alexander WeissDonnelly Centre, University of Toronto, Toronto, Canada.
Levi L BlazerDonnelly Centre, University of Toronto, Toronto, Canada.ORCID 0000-0001-9594-4642
Marcin PaduchInstitute for Biophysical Dynamics, Gordon Center for Integrative Science, Chicago, USA.
Lia CardarelliDonnelly Centre, University of Toronto, Toronto, Canada.
Anthony KossiakoffInstitute for Biophysical Dynamics, Gordon Center for Integrative Science, Chicago, USA.
Jarrett J AdamsDonnelly Centre, University of Toronto, Toronto, Canada.
Sachdev S SidhuDonnelly Centre, University of Toronto, Toronto, Canada.
University of Toronto · CAUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to direct T cells to specific features of solid cancer cells, we engineered a bispecific antibody format, named

Indexed as

AnimalsAntibodies, BispecificAntibodies, Monoclonal, HumanizedAntigens, NeoplasmAntineoplastic AgentsCarcinoma, Pancreatic DuctalCD3 ComplexHumansImmunotherapyLymphocyte ActivationMicePancreatic NeoplasmsT-LymphocytesXenograft Model Antitumor AssaysAntibodies, BispecificAntibodies, Monoclonal, HumanizedAntigens, NeoplasmAntineoplastic AgentsCD3 ComplexAntibody/immunotherapy/pancreatic cancer/solid tumors/T-cell redirection/CD133/EPHA2/EPCAM/EPHB2/dual targeting

Identifiers

PMID34190031
PMCPMC8253144
OpenAlexW3176850572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.