An integrated DNA and RNA variant detector identifies a highly conserved three base exon in the
Małgorzata Kurkowiak, Giuseppa Grasso, Jakub Faktor, Lisa Scheiblecker, Małgorzata Winniczuk, Marcos Yebenes Mayordomo, J Robert O'Neill, Bodil Oster, Borek Vojtesek, Ali Al-Saadi and 2 more
Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
Borek VojtesekResearch Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Ali Al-SaadiUniversity of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh Cancer Research Centre, Edinburgh, Scotland, UK.
Natalia Marek-TrzonkowskaInternational Centre for Cancer Vaccine Science (ICCVS), University of Gdańsk, 80-822 Gdańsk, Poland.ORCID 0000-0003-1201-295X
Ted R HuppInternational Centre for Cancer Vaccine Science (ICCVS), University of Gdańsk, 80-822 Gdańsk, Poland.ORCID 0000-0003-0391-0352
Edinburgh Cancer Research · GBUniversity of Gdańsk · PLCambridge University Hospitals NHS Foundation Trust · GBMasaryk Memorial Cancer Institute · CZUniversity of Veterinary Medicine Vienna · AT
Funding
Biotechnology and Biological Sciences Research Council BB/C511599/1Wellcome TrustWellcome Trust 094417/Z/10/Z
6 · The paper itself
Abstract
RNA variants that emerge from editing and alternative splicing form important regulatory stages in protein signalling. In this report, we apply an integrated DNA and RNA variant detection workbench to define the range of RNA variants that deviate from the reference genome in a human melanoma cell model. The RNA variants can be grouped into (i) classic ADAR-like or APOBEC-like RNA editing events and (ii) multiple-nucleotide variants (MNVs) including three and six base pair in-frame non-canonical unmapped exons. We focus on validating representative genes of these classes. First, clustered non-synonymous RNA edits (A-I) in the
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
An integrated DNA and RNA variant detector identifies a highly conserved three base exon in the · full record | OpenQuestion