Evidence map›Paper›PMID 34190021›Full record

ArticleHuman fertility (Cambridge, England)2022

Screening by single-molecule molecular inversion probes targeted sequencing panel of candidate genes of infertility in azoospermic infertile Jordanian males.

Osamah Batiha, George J Burghel, Ayesha Alkofahi, Emad Alsharu, Hannah Smith, Bilal Alobaidi, Mohammad Al-Smadi, Nour Awamlah, Lama Hussein, Amid Abdelnour and 2 more

Open access · greenAbstract read
In one paragraph

Article in Human fertility (Cambridge, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Osamah BatihaDepartment of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid, Jordan.
George J BurghelThe Manchester Centre for Genomic Medicine, University of Manchester NHS Foundation Trust, Manchester, UK.
Ayesha AlkofahiDepartment of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid, Jordan.
Emad AlsharuReproductive Endocrinology and IVF Unit, King Hussein Medical Center, Amman, Jordan.
Hannah SmithBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Bilal AlobaidiBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Mohammad Al-SmadiReproductive Endocrinology and IVF Unit, King Hussein Medical Center, Amman, Jordan.
Nour AwamlahBiolab Diagnostic Laboratories, Amman, Jordan.
Lama HusseinBiolab Diagnostic Laboratories, Amman, Jordan.
Amid AbdelnourBiolab Diagnostic Laboratories, Amman, Jordan.
Harsh ShethBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0001-9626-0971
Joris VeltmanBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Newcastle University · GBJordan University of Science and Technology · JOKing Hussein Medical Center · JOCentre For Human Genetics · INUniversity of Manchester · GB

Funding

Wellcome Trust 209451Wellcome Trust 209451/Z/17/Z
6 · The paper itself

Abstract

Infertility is a common health problem that affects around 1 in 6 couples in the United States, where half of these cases are attributed to male factors. Genetics play an important role in infertility and it is estimated that up to 50% of cases are due to genetic factors. Despite this, many male infertility cases are still idiopathic. This study aimed to identify the presence of possibly pathogenic rare variants in a set of candidate genes related to azoospermia in 69 Jordanian men using a next-generation sequencing-based panel covering more than a hundred male infertility related genes. A total of 9 variants were found and validated. Among them, two variants included reported pathogenic variants in

Indexed as

AzoospermiaInfertility, MaleOligospermiaCystic Fibrosis Transmembrane Conductance RegulatorHumansJordanMaleMutationCystic Fibrosis Transmembrane Conductance RegulatorAzoospermiaCFTR mutationsMale infertilitynext generation sequencingsingle-molecule Molecular Inversion Probes

Identifiers

PMID34190021
PMCPMC7614817
OpenAlexW3176804615

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.