Evidence map›Paper›PMID 34190015›Full record

ArticleTechnology in cancer research & treatment

A Prognostic Model for Patients With Gastric Signet Ring Cell Carcinoma.

Qinping Guo, Yinquan Wang, Jie An, Siben Wang, Xiushan Dong, Haoliang Zhao

Abstract readValidation Study
In one paragraph

Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qinping GuoDepartment of General Surgery, Shanxi Bethune Hospital, Taiyuan, Shanxi Province, China.
Yinquan WangDepartment of General Surgery, Shanxi Bethune Hospital, Taiyuan, Shanxi Province, China.
Jie AnDepartment of General Surgery, Shanxi Bethune Hospital, Taiyuan, Shanxi Province, China.
Siben WangDepartment of Thoracic Surgery, Huainan First People's Hospital, Huainan, Anhui Province, China.
Xiushan DongDepartment of General Surgery, Shanxi Bethune Hospital, Taiyuan, Shanxi Province, China.
Haoliang ZhaoDepartment of General Surgery, Shanxi Bethune Hospital, Taiyuan, Shanxi Province, China.ORCID 0000-0002-9761-9357

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of our study was to develop a nomogram model to predict overall survival (OS) and cancer-specific survival (CSS) in patients with gastric signet ring cell carcinoma (GSRC).

methodsGSRC patients from 2004 to 2015 were collected from the Surveillance, Epidemiology, and End Results (SEER) database and randomly assigned to the training and validation sets. Multivariate Cox regression analyses screened for OS and CSS independent risk factors and nomograms were constructed.

resultsA total of 7,149 eligible GSRC patients were identified, including 4,766 in the training set and 2,383 in the validation set. Multivariate Cox regression analysis showed that gender, marital status, race, AJCC stage, TNM stage, surgery and chemotherapy were independent risk factors for both OS and CSS. Based on the results of the multivariate Cox regression analysis, prognostic nomograms were constructed for OS and CSS. In the training set, the C-index was 0.754 (95% CI = 0.746-0.762) for the OS nomogram and 0.762 (95% CI: 0.753-0.771) for the CSS nomogram. In the internal validation, the C-index for the OS nomogram was 0.758 (95% CI: 0.746-0.770), while the C-index for the CSS nomogram was 0.762 (95% CI: 0.749-0.775). Compared with TNM stage and SEER stage, the nomogram had better predictive ability. In addition, the calibration curves also showed good consistency between the predicted and actual 3-year and 5-year OS and CSS.

conclusionThe nomogram can effectively predict OS and CSS in patients with GSRC, which may help clinicians to personalize prognostic assessments and clinical decisions.

Indexed as

NomogramsAbdominal NeoplasmsAgedAged, 80 and overAntineoplastic AgentsCarcinoma, Signet Ring CellFemaleGastrectomyHumansMaleMarital StatusMiddle AgedPrognosisProportional Hazards ModelsRace FactorsSEER ProgramAntineoplastic Agentscancer-specific survivalgastric signet ring cell carcinomanomogramoverall survivalSEER

Identifiers

PMID34190015
PMCPMC8258759

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.