Evidence map›Paper›PMID 34189769›Full record

ArticleIndoor air2021

Identification of SARS-CoV-2 RNA in healthcare heating, ventilation, and air conditioning units.

Patrick F Horve, Leslie G Dietz, Mark Fretz, David A Constant, Andrew Wilkes, John M Townes, Robert G Martindale, William B Messer, Kevin G Van Den Wymelenberg

Abstract read
In one paragraph

Article in Indoor air, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Detection of SARS-CoV-2 RNA on air purifier filters in university spaces without symptomatic or confirmed cases.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2025
    Article
  2. Article
  3. Article
  4. Air Change Rate and SARS-CoV-2 Exposure in Hospitals and Residences: A Meta-Analysis.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Passively sensing SARS-CoV-2 RNA in public transit buses.The Science of the total environment · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Patrick F HorveBiology and the Built Environment Center, University of Oregon, Eugene, OR, USA.ORCID 0000-0002-9318-9249
Leslie G DietzBiology and the Built Environment Center, University of Oregon, Eugene, OR, USA.ORCID 0000-0002-5623-1524
Mark FretzInstitute for Health in the Built Environment, University of Oregon, Portland, OR, USA.ORCID 0000-0003-3712-9724
David A ConstantDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0001-9656-078X
Andrew WilkesHealthcare Facilities, Oregon Health and Science University, Portland, OR, USA.
John M TownesDivision of Infectious Diseases, Department of Medicine, School of Medicine, Oregon Health and Science University, Portland, OR, USA.
Robert G MartindaleDivision of Gastrointestinal and General Surgery, School of Medicine, Oregon Health and Science University, Portland, OR, USA.
William B MesserDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.
Kevin G Van Den WymelenbergBiology and the Built Environment Center, University of Oregon, Eugene, OR, USA.ORCID 0000-0002-0336-5537

Funding

Oregon Health and Science FoundationUniversity of Oregon and Oregon Health and Science University seed research funds
6 · The paper itself

Abstract

Evidence continues to grow supporting the aerosol transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To assess the potential role of heating, ventilation, and air conditioning (HVAC) systems in airborne viral transmission, this study sought to determine the viral presence, if any, on air handling units in a healthcare setting where coronavirus disease 2019 (COVID-19) patients were being treated. The presence of SARS-CoV-2 RNA was detected in approximately 25% of samples taken from ten different locations in multiple air handlers. While samples were not evaluated for viral infectivity, the presence of viral RNA in air handlers raises the possibility that viral particles can enter and travel within the air handling system of a hospital, from room return air through high-efficiency MERV-15 filters and into supply air ducts. Although no known transmission events were determined to be associated with these specimens, the findings suggest the potential for HVAC systems to facilitate transfer of virions to locations remote from areas where infected persons reside. These results are important within and outside of healthcare settings and may present necessary guidance for building operators of facilities that are not equipped with high-efficiency filtration. Furthermore, the identification of SARS-CoV-2 in HVAC components indicates the potential utility as an indoor environmental surveillance location.

Indexed as

Air ConditioningAir Pollution, IndoorAir MicrobiologyCOVID-19Delivery of Health CareHeatingHospitalsHumansRNA, ViralSARS-CoV-2VentilationRNA, ViralaerosolsCOVID-19filtrationhealthcareHVACMERVSARS-CoV-2

Identifiers

PMID34189769
PMCPMC8447041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.