ArticleSocial cognitive and affective neuroscience2023
Orbitofrontal cortex connectivity is associated with food reward and body weight in humans.
Article in Social cognitive and affective neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Tirzepatide on ingestive behavior in adults with overweight or obesity: a randomized 6-week phase 1 trial.Nature medicine · 2025Trial
- Representational structure of perceived food attributes in human occipitotemporal cortex.iScience · 2026Article
- Interaction of physical activity and gut-brain axis: relevance for obesity.Reviews in endocrine & metabolic disorders · 2026Review
- Machine learning-based identification of abnormal functional connectivity in obesity across different metabolic states.Communications medicine · 2026Article
- Acute aerobic exercise modulates sweetness-related food preference in individuals with nicotine dependence: the mediating role of prefrontal cortical activity.Frontiers in nutrition · 2026Article
- The Interplay Between Psychological and Neurobiological Predictors of Weight Regain: A Narrative Review.Nutrients · 2025Review
- Selective Brain Activations and Connectivities Related to the Storage and Recall of Human Object-Location, Reward-Location, and Word-Pair Episodic Memories.Human brain mapping · 2024Article
- A ventromedial visual cortical 'Where' stream to the human hippocampus for spatial scenes revealed with magnetoencephalography.Communications biology · 2024Article
- A Neural Mechanism in the Human Orbitofrontal Cortex for Preferring High-Fat Foods Based on Oral Texture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Interaction of Glycemia with Anxiety and Depression Is Related to Altered Cerebellar and Cerebral Functional Correlations.Brain sciences · 2023Article
- Central Regulation of Eating Behaviors in Humans: Evidence from Functional Neuroimaging Studies.Nutrients · 2023Review
- Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala.Brain structure & function · 2023Review
- The orbitofrontal cortex, food reward, body weight and obesity.Social cognitive and affective neuroscience · 2023Article
- The social neuroscience of eating: an introduction to the special issue.Social cognitive and affective neuroscience · 2023Article
- The body mass index is associated with increased temporal variability of functional connectivity in brain reward system.Frontiers in nutrition · 2023Article
- Obesity mechanism after hypothalamic damage: Cohort analysis of neuroimaging, psychological, cognitive, and clinical phenotyping data.Frontiers in endocrinology · 2023Article
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Authors and funding
4 authors.
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Abstract
The aim was to investigate with very large-scale analyses whether there are underlying functional connectivity differences between humans that relate to food reward and whether these in turn are associated with being overweight. In 37 286 humans from the UK Biobank, resting-state functional connectivities of the orbitofrontal cortex (OFC), especially with the anterior cingulate cortex, were positively correlated with the liking for sweet foods (False Discovery Rate (FDR) P < 0.05). They were also positively correlated with the body mass index (BMI) (FDR P < 0.05). Moreover, in a sample of 502 492 people, the 'liking for sweet foods' was correlated with their BMI (r = 0.06, P < 10-125). In a cross-validation with 545 participants from the Human Connectome Project, a higher functional connectivity involving the OFC relative to other brain areas was associated with a high BMI (≥30) compared to a mid-BMI group (22-25; P = 6 × 10-5), and low OFC functional connectivity was associated with a low BMI (≤20.5; P < 0.024). It is proposed that a high BMI relates to increased efficacy of OFC food reward systems and a low BMI to decreased efficacy. This was found with no stimulation by food, so may be an underlying individual difference in brain connectivity that is related to food reward and BMI.
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