Evidence map›Paper›PMID 34189527›Full record

ArticlebioRxiv : the preprint server for biology2021

CHARMM-GUI Membrane Builder for Lipid Nanoparticles with Ionizable Cationic Lipids and PEGylated Lipids.

Soohyung Park, Yeol Kyo Choi, Seonghoon Kim, Jumin Lee, Wonpil Im

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Soohyung ParkDepartment of Biological Sciences, Chemistry, Bioengineering, and Computer Science and Engineering, Lehigh University, PA, USA.
Yeol Kyo ChoiDepartment of Biological Sciences, Chemistry, Bioengineering, and Computer Science and Engineering, Lehigh University, PA, USA.
Seonghoon KimSchool of Computational Sciences, Korea Institute for Advanced Study, Seoul, Republic of Korea.
Jumin LeeDepartment of Biological Sciences, Chemistry, Bioengineering, and Computer Science and Engineering, Lehigh University, PA, USA.
Wonpil ImDepartment of Biological Sciences, Chemistry, Bioengineering, and Computer Science and Engineering, Lehigh University, PA, USA.
Lehigh University · USKorea Institute for Advanced Study · KR

Funding

CHARMM-GUI Development for Biomolecular Modeling and Simulation CommunityR01GM138472 · NIGMS · LEHIGH UNIVERSITY · PI IM, WONPIL · 2020 to 2023
$1.5M
NIGMS NIH HHS R01 GM138472
6 · The paper itself

Abstract

A lipid nanoparticle (LNP) formulation is a state-of-the-art delivery system for genetic drugs such as DNA, mRNA, and siRNA, which is successfully applied to COVID-19 vaccines and gains tremendous interest in therapeutic applications. Despite its importance, a molecular-level understanding of the LNP structures and dynamics is still lacking, which makes a rational LNP design almost impossible. In this work, we present an extension of CHARMM-GUI

Identifiers

PMID34189527
PMCPMC8240680
OpenAlexW3174667050

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.