Evidence map›Paper›PMID 34189496›Full record

ArticleIBRO neuroscience reports2021

Reversal of motor-skill transfer impairment by trihexyphenidyl and reduction of dorsolateral striatal cholinergic interneurons in

Fumiaki Yokoi, Mai Tu Dang, Lin Zhang, Kelly M Dexter, Iakov Efimenko, Shiv Krishnaswamy, Matthew Villanueva, Carly I Misztal, Malinda Gerard, Patrick Lynch and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO neuroscience reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Fumiaki YokoiNorman Fixel Institute of Neurological Diseases, McKnight Brain Institute, and Department of Neurology, College of Medicine, University of Florida, Gainesville, FL 32610-0236, USA.
Mai Tu DangDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Lin ZhangNorman Fixel Institute of Neurological Diseases, McKnight Brain Institute, and Department of Neurology, College of Medicine, University of Florida, Gainesville, FL 32610-0236, USA.
Kelly M DexterNorman Fixel Institute of Neurological Diseases, McKnight Brain Institute, and Department of Neurology, College of Medicine, University of Florida, Gainesville, FL 32610-0236, USA.
Iakov EfimenkoNorman Fixel Institute of Neurological Diseases, McKnight Brain Institute, and Department of Neurology, College of Medicine, University of Florida, Gainesville, FL 32610-0236, USA.
Shiv KrishnaswamyNorman Fixel Institute of Neurological Diseases, McKnight Brain Institute, and Department of Neurology, College of Medicine, University of Florida, Gainesville, FL 32610-0236, USA.
Matthew VillanuevaNorman Fixel Institute of Neurological Diseases, McKnight Brain Institute, and Department of Neurology, College of Medicine, University of Florida, Gainesville, FL 32610-0236, USA.
Carly I MisztalNorman Fixel Institute of Neurological Diseases, McKnight Brain Institute, and Department of Neurology, College of Medicine, University of Florida, Gainesville, FL 32610-0236, USA.
Malinda GerardNorman Fixel Institute of Neurological Diseases, McKnight Brain Institute, and Department of Neurology, College of Medicine, University of Florida, Gainesville, FL 32610-0236, USA.
Patrick LynchNorman Fixel Institute of Neurological Diseases, McKnight Brain Institute, and Department of Neurology, College of Medicine, University of Florida, Gainesville, FL 32610-0236, USA.
Yuqing LiNorman Fixel Institute of Neurological Diseases, McKnight Brain Institute, and Department of Neurology, College of Medicine, University of Florida, Gainesville, FL 32610-0236, USA.
University of Florida · USChildren's Hospital of Philadelphia · US

Funding

Non-Invasive Markers of Neurodegeneration in Movement DisordersR01NS075012 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING, VAILLANCOURT, DAVID E · 2012 to 2022
$4.1M
Restless Legs Syndrome: Pathophysiology using Btbd9 Conditional Knockout MiceR01NS082244 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING · 2014 to 2018
$1.6M
Pathophysiology of DYT1 Dystonia: Targeted Mouse ModelsR01NS054246 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING · 2007 to 2010
$1.4M
Characterization of Meis1 mutant mice and implications in restless legs syndrome and other sleep disordersR21NS111498 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING · 2020 to 2021
$419k
Characterization of the involvement of the cerebellum in animal models of C9orf72 ALS/FTDR21NS118397 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING · 2020 to 2020
$419k
Rapid-onset Dystonia Parkinsonism (DYT12 Dystonia): Pathophysiology & Atp1a3 MiceR21NS072872 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING · 2010 to 2011
$399k
NINDS NIH HHS R01 NS054246NINDS NIH HHS R01 NS075012NINDS NIH HHS R01 NS082244NINDS NIH HHS R21 NS072872NINDS NIH HHS R21 NS111498NINDS NIH HHS R21 NS118397
6 · The paper itself

Abstract

DYT-TOR1A or DYT1 early-onset generalized dystonia is an inherited movement disorder characterized by sustained muscle contractions causing twisting, repetitive movements, or abnormal postures. The majority of the DYT1 dystonia patients have a trinucleotide GAG deletion in

Indexed as

ACh, acetylcholineAChE, acetylcholinesteraseBSA, bovine serum albuminChAT, choline acetyltransferaseChI, cholinergic interneuronCholinergic interneuronChT, choline transporterCI, confidence intervalDAB, 3,3′-diaminobenzidineDF, degrees of freedomDystoniaDyt1 KI mice, Dyt1 ΔGAG heterozygous knock-in miceGAPDH, Glyceraldehyde-3-phosphate dehydrogenaseKO, knockoutLTD, long-term depressionMotor learningn.s., not significantPB, phosphate bufferPBS, phosphate-buffered salinePET, positron emission tomographyRotarodTHP, trihexyphenidylTOR1ATorsinATrkA, tropomyosin receptor kinase AVAChT, vesicular acetylcholine transporterWT, wild-type

Identifiers

PMID34189496
PMCPMC8215213
OpenAlexW3167853257

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.