Evidence map›Paper›PMID 34189460›Full record

ArticleBrain communications2021

Interactive rather than independent effect of

Yi-Ting T Wang, Tharick A Pascoal, Joseph Therriault, Min Su Kang, Andréa L Benedet, Melissa Savard, Cécile Tissot, Firoza Z Lussier, Jaime Fernandez Arias, Sulantha Mathotaarachchi and 4 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Sex differences inFrontiers in dementia · 2025
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Factors associated with age at tau pathology onset and time from tau onset to dementia in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Brain communications · 2025
    Article
  14. Review
  15. Article
  16. LRRK2-Associated Parkinsonism With and WithoutmedRxiv : the preprint server for health sciences · 2024
    Article
  17. Observational
  18. Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Observational
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Yi-Ting T WangTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Tharick A PascoalDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Joseph TherriaultTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.ORCID https://orcid.org/0000-0002-7826-4781
Min Su KangTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.ORCID https://orcid.org/0000-0003-0745-6222
Andréa L BenedetTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.ORCID https://orcid.org/0000-0001-9057-8014
Melissa SavardTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Cécile TissotTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Firoza Z LussierTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.ORCID https://orcid.org/0000-0002-6877-4825
Jaime Fernandez AriasTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Sulantha MathotaarachchiTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Maria Natasha RajahDouglas Research Centre, Montréal, QC, Canada.
Serge GauthierTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada.
Alzheimer’s Disease Neuroimaging Initiative
Douglas College · CAMcGill University · CAUniversity of Pittsburgh · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

The apolipoprotein E gene (

Indexed as

Alzheimer’s diseaseAPOEpositron emission tomographysex differencetau

Identifiers

PMID34189460
PMCPMC8226193
OpenAlexW3168209799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.