Evidence map›Paper›PMID 34189408›Full record

ArticleJournal of Alzheimer's disease reports2021

More Atypical than Atypical Alzheimer's Disease Phenotypes: A Treviso Dementia (TREDEM) Registry Case Report.

Maurizio Gallucci, Anna Paola Mazzarolo, Lucia Focella, Elisa Berlin, Vittorio Fiore, Francesco Di Paola, Matteo Bendini, Gianluigi Zanusso, Chiara Fenoglio, Daniela Galimberti and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of Alzheimer's disease reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Maurizio GallucciCognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy.ORCID https://orcid.org/0000-0001-6329-319
Anna Paola MazzaroloCognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy.
Lucia FocellaCognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy.
Elisa BerlinCognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy.
Vittorio FioreNuclear Medicine Unit, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy.
Francesco Di PaolaNeuroradiology Unit, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy.
Matteo BendiniNeuroradiology Unit, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy.
Gianluigi ZanussoDepartment of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.
Chiara FenoglioUniversity of Milan, Dino Ferrari Center, Milan, Italy.
Daniela GalimbertiUniversity of Milan, Dino Ferrari Center, Milan, Italy.
Laura BonanniDepartment of Neuroscience Imaging and Clinical Sciences and CESI, University G D'Annunzio of Chieti-Pescara, Chieti, Italy.
AULSS 2 Marca Trevigiana · ITUniversity of Milan · ITUniversity of Chieti-Pescara · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA 57-year-old right-handed man was admitted to the Treviso Memory Clinic due to the presence of memory forgetfulness, repetition of the same questions, episodes of confusion, initial difficulties in performing complex tasks and easy distraction over the past two years, as well as recurrent and never-happened-before car accidents.

objectiveWe report a peculiar case of an early onset Alzheimer's disease (AD) with an unusual symptomatology, apparently not fitting in any of the categorized atypical forms of AD nor being representative of a typical amnestic AD.

methodsThe patient underwent a neuropsychological, structural, and metabolic cerebral evaluation by MRI and

resultsWe observed a convergence of predominant frontal (dysexecutive, verbal disinhibition) and posterior (visuospatial) features of cognitive impairment. Structural MRI sequences showed subarachnoid spaces of the vault enlarged in the fronto-parietal region with anterior and posterior cortical atrophy. The hippocampus appeared preserved. The

conclusionThis case report presented with clinical phenotypic aspects atypical of AD, both frontal and posterior, never described as concomitant in the most accredited criteria for atypical AD, and appeared therefore more atypical than each of the atypical AD phenotypes already reported.

Indexed as

Alzheimer’s diseasefrontal variantmagnetic resonanceneurodegenerative diseasesPET scanposterior cortical atrophyTREDEM

Identifiers

PMID34189408
PMCPMC8203287
OpenAlexW3165818307

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.