ArticleNetwork neuroscience (Cambridge, Mass.)2021
MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture.
Article in Network neuroscience (Cambridge, Mass.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Impact of disease duration and surgical intervention on arousal networks in temporal lobe epilepsy.Journal of neurosurgery · 2025Article
- Quantification of brain functional connectivity deviations in individuals: A scoping review of functional MRI studies.NeuroImage. Clinical · 2025Article
- Article
- Abnormal functional connectivity of the posterior hypothalamus and other arousal regions in surgical temporal lobe epilepsy.Journal of neurosurgery · 2023Article
- Mahalanobis distance tractometry (MaD-Tract) - a framework for personalized white matter anomaly detection applied to TBI.NeuroImage · 2022Article
- Patient-specific structural connectivity informs outcomes of responsive neurostimulation for temporal lobe epilepsy.Epilepsia · 2022Article
- Advanced neuroimaging techniques in epilepsy.Current opinion in neurology · 2022Review
- Reward-based decision-making in mesial temporal lobe epilepsy patients with unilateral hippocampal sclerosis pre- and post-surgery.NeuroImage. Clinical · 2022Article
- Volumetric and structural connectivity abnormalities co-localise in TLE.NeuroImage. Clinical · 2022Article
- Presurgical temporal lobe epilepsy connectome fingerprint for seizure outcome prediction.Brain communications · 2022Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
We measured MRI network progression in mesial temporal lobe epilepsy (mTLE) patients as a function of healthy brain architecture. Resting-state functional MRI and diffusion-weighted MRI were acquired in 40 unilateral mTLE patients and 70 healthy controls. Data were used to construct region-to-region functional connectivity, structural connectivity, and streamline length connectomes per subject. Three models of distance from the presumed seizure focus in the anterior hippocampus in the healthy brain were computed using the average connectome across controls. A fourth model was defined using regions of transmodal (higher cognitive function) to unimodal (perceptual) networks across a published functional gradient in the healthy brain. These models were used to test whether network progression in patients increased when distance from the anterior hippocampus or along a functional gradient in the healthy brain decreases. Results showed that alterations of structural and functional networks in mTLE occur in greater magnitude in regions of the brain closer to the seizure focus based on healthy brain topology, and decrease as distance from the focus increases over duration of disease. Overall, this work provides evidence that changes across the brain in focal epilepsy occur along healthy brain architecture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.