ArticleNetwork neuroscience (Cambridge, Mass.)2021
The R1-weighted connectome: complementing brain networks with a myelin-sensitive measure.
Article in Network neuroscience (Cambridge, Mass.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The microstructure-weighted human connectome: network properties and structure-function correlations across spatial scales.bioRxiv : the preprint server for biology · 2026Article
- The role of white matter myelin in structural-functional network coupling.Communications biology · 2026Article
- A pilot study on protocol consistency and graph metric reproducibility in microstructure-weighted connectomes.Scientific reports · 2026Article
- Mapping the aggregate g-ratio of white matter tracts using multi-modal MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A multi-modal, asymmetric, weighted, and signed description of anatomical connectivity.Nature communications · 2024Article
- Towards a biologically annotated brain connectome.Nature reviews. Neuroscience · 2023Review
- Multi-modal and multi-model interrogation of large-scale functional brain networks.NeuroImage · 2023Article
- Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia.Brain : a journal of neurology · 2023Article
- Evaluation of tractography-based myelin-weighted connectivity across the lifespan.Frontiers in neuroscience · 2023Article
- The human brain connectome weighted by the myelin content and total intra-axonal cross-sectional area of white matter tracts.Network neuroscience (Cambridge, Mass.) · 2023Article
- Quantitative mapping of the brain's structural connectivity using diffusion MRI tractography: A review.NeuroImage · 2022Review
- Bundle myelin fraction (BMF) mapping of different white matter connections using microstructure informed tractography.NeuroImage · 2022Article
- The Myelin-Weighted Connectome in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- The hidden community architecture of human brain networks.Scientific reports · 2022Article
- Whole-Brain Network Models: From Physics to Bedside.Frontiers in computational neuroscience · 2022Review
- Resolving bundle-specific intra-axonal TNeuroImage · 2021Article
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7 authors.
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Abstract
Myelin plays a crucial role in how well information travels between brain regions. Complementing the structural connectome, obtained with diffusion MRI tractography, with a myelin-sensitive measure could result in a more complete model of structural brain connectivity and give better insight into white-matter myeloarchitecture. In this work we weight the connectome by the longitudinal relaxation rate (R1), a measure sensitive to myelin, and then we assess its added value by comparing it with connectomes weighted by the number of streamlines (NOS). Our analysis reveals differences between the two connectomes both in the distribution of their weights and the modular organization. Additionally, the rank-based analysis shows that R1 can be used to separate transmodal regions (responsible for higher-order functions) from unimodal regions (responsible for low-order functions). Overall, the R1-weighted connectome provides a different perspective on structural connectivity taking into account white matter myeloarchitecture.
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