Evidence map›Paper›PMID 34189279›Full record

ArticleBiochemistry and biophysics reports2021

Functional evidence of distinct electrophile-induced activation states of the ion channel TRPA1.

Thomas A Parks, Parmvir K Bahia, Thomas E Taylor-Clark

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Sensory TRP Channels in Three Dimensions.Annual review of biochemistry · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Thomas A ParksDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Parmvir K BahiaDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Thomas E Taylor-ClarkDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
University of South Florida · US

Funding

Remodeled airway irritant reflexes as a cause of serious cardiovascular eventsR01HL152219 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI TAYLOR-CLARK, THOMAS EDWARD · 2021 to 2024
$2.1M
Mitochondrial reactive oxygen species induce airway sensory nerve activityR01HL119802 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI TAYLOR-CLARK, THOMAS EDWARD · 2013 to 2017
$2.0M
NHLBI NIH HHS R01 HL119802NHLBI NIH HHS R01 HL152219
6 · The paper itself

Abstract

Transient Receptor Potential Ankyrin 1 (TRPA1) is a tetrameric, nonselective cation channel expressed on nociceptive sensory nerves whose activation elicits nocifensive responses (e.g. pain). TRPA1 is activated by electrophiles found in foods and pollution, or produced during inflammation and oxidative stress, via covalent modification of reactive cysteines, but the mechanism underlying electrophilic activation of TRPA1 is poorly understood. Here we studied TRPA1 activation by the irreversible electrophiles iodoacetamide and N-ethylmaleimide (NEM) following transient expression in HEK293 cells. We found that in Ca

Indexed as

ActivationCysteineElectrophileGlutathioneTRPA1

Identifiers

PMID34189279
PMCPMC8219651
OpenAlexW3173186815

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.