Evidence map›Paper›PMID 34189276›Full record

ArticleJournal of clinical tuberculosis and other mycobacterial diseases2021

Facility-based directly observed therapy (DOT) for tuberculosis during COVID-19: A community perspective.

Alexandra J Zimmer, Petra Heitkamp, James Malar, Cintia Dantas, Kate O'Brien, Aakriti Pandita, Robyn C Waite

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Impact of the COVID-19 pandemic on tuberculosis program performance in Alberta, Canada: a population-based evaluation.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
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  10. Co-infection of mice with SARS-CoV-2 andFrontiers in immunology · 2023
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  11. Article
  12. Article
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  14. Article
  15. Tuberculosis in times of COVID-19.Journal of epidemiology and community health · 2022
    Article
  16. Article
  17. Article
  18. The Effect of COVID-19 on Tuberculosis Care and Treatment Outcome in Pre-COVID, COVID, and Post-COVID Eras.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alexandra J ZimmerDepartment of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Canada.
Petra HeitkampMcGill International TB Centre, Montreal, Canada.
James MalarStop TB Partnership, Geneva, Switzerland.
Cintia DantasGlobal TB Caucus, London, UK.
Kate O'BrienWe are TB/National TB Controllers Association, Smryna, USA.
Aakriti PanditaDivision of Infectious Diseases, University of Colorado School of Medicine, Denver, USA.
Robyn C WaiteResults Canada, Ottawa, Canada.
McGill University · CAMcGill University Health Centre · CAUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Facility-based directly observed therapy (DOT) has been the standard for treating people with TB since the early 1990s. As the commitment to promote a people-centred model of care for TB grows, the use of facility-based DOT has been questioned as issues of freedom, privacy, and human rights have been raised. The disruptions caused by the COVID-19 pandemic and ensuing lockdown measures have fast-tracked the need to find alternative methods to provide treatment to people with TB. In this study, we present quantitative and qualitative findings from a global community-based survey on the challenges of administering facility-based DOT during a pandemic as well as potential alternatives. Our results found that decreased access to transportation, the fear of COVID-19, stigmatization due to overlapping symptoms, and punitive measures against quarantine violations have made it difficult for persons with TB to receive treatment at facilities, particularly in low-resource settings. Potential replacements included greater focus on community-based DOT, home delivery of treatment, multi-month dispensing, and video DOT strategies. Our study highlights the need for TB programs to re-evaluate their approach to providing treatment to people with TB, and that these changes must be made in consultation with people affected by TB and TB survivors to provide a true people-centred model of care.

Indexed as

COVID-19Directly observed therapyHuman rightsTuberculosis

Identifiers

PMID34189276
PMCPMC8225462
OpenAlexW3176824761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.