Evidence map›Paper›PMID 34189247›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021

The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics.

Sid E O'Bryant, Leigh A Johnson, Robert C Barber, Meredith N Braskie, Bradley Christian, James R Hall, Nalini Hazra, Kevin King, Deydeep Kothapalli, Stephanie Large and 15 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed.

  1. Article
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  6. Cross-ancestry polygenic risk scores enhance Alzheimer's disease risk prediction in multiethnic cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  7. Article
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  10. Associations of dementia polyexposure scores to Alzheimer's disease endophenotypes in a diverse population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  11. Chronic stress, social support, and domain-specific cognitive decline in HABS-HD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  12. Article
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  15. Article
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  17. Alcohol use andAlzheimer's & dementia. Behavior & socioeconomics of aging · 2026
    Article
  18. Article
  19. Article
  20. Ancestry-specific effects ofmedRxiv : the preprint server for health sciences · 2026
    Article

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Sid E O'BryantInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Leigh A JohnsonInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Robert C BarberInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Meredith N BraskieImaging Genetics Center, Stevens Neuroimaging and Informatics Institute Keck School of Medicine, USC Los Angeles California USA.
Bradley ChristianWaisman Center, Departments of Physics and Psychiatry University of Wisconsin Madison Madison Wisconsin USA.
James R HallInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Nalini HazraImaging Genetics Center, Stevens Neuroimaging and Informatics Institute Keck School of Medicine, USC Los Angeles California USA.
Kevin KingDepartment of Neuroradiology Barrow Neurological Institute Phoenix Arizona USA.
Deydeep KothapalliImaging Genetics Center, Stevens Neuroimaging and Informatics Institute Keck School of Medicine, USC Los Angeles California USA.
Stephanie LargeInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
David MasonDepartment of Family Medicine University of North Texas Health Science Center Fort Worth Texas USA.
Elizabeth MatsiyevskiyImaging Genetics Center, Stevens Neuroimaging and Informatics Institute Keck School of Medicine, USC Los Angeles California USA.
Roderick McCollDepartment of Radiology UT Southwestern Medical Center Dallas Texas USA.
Rajesh NandyInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Raymond PalmerDepartment of Family Practice and Community Medicine, Joe R & Teresa Lozano Long School of Medicine The University of Texas Health Science Center at San Antonio San Antonio Texas USA.
Melissa PetersenInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Nicole PhilipsInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Robert A RissmanDepartment of Neurosciences University of California San Diego, La Jolla California USA.
Yonggang ShiLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC University of Southern California Los Angeles California USA.
Arthur W TogaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC University of Southern California Los Angeles California USA.
Raul VintimillaInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Rocky VigImaging, Midtown Medical Imaging Fort Worth Texas USA.
Fan ZhangInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Kristine YaffeDepartment of Psychiatry, Neurology, and Epidemiology and Biostatistics University of California San Francisco California USA.
HABLE Study Team

Funding

The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Sid E O'Bryant · 2022 to 2026
$181.1M
Health and Aging Brain among Latino Elders (HABLE-AT(N)) StudyR01AG058533 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JOHNSON, LEIGH A, O'BRYANT, SID E · 2020 to 2025
$45.4M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
The Aging Brain: Vasculature, Ischemia, and BehaviorP01AG012435 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI REED, BRUCE · 1994 to 2012
$26.4M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican AmericansR01AG054073 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E, TOGA, ARTHUR W · 2017 to 2021
$12.6M
NIA NIH HHS P01 AG012435NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG054073NIA NIH HHS R01 AG058533NIA NIH HHS U19 AG078109NIBIB NIH HHS P41 EB015922
6 · The paper itself

Abstract

introductionMexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature.

methodsCommunity-dwelling Mexican Americans and non-Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository.

resultsData was examined from n = 1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non-Hispanic Whites. DISCUSSION: The current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations.

Indexed as

Alzheimer's diseaseamyloidbiomarkersdiversityHispanicMexican Americanmild cognitive impairmentneurodegeneration

Identifiers

PMID34189247
PMCPMC8215806

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.