Evidence map›Paper›PMID 34189206›Full record

ArticleData in brief2021

Transcriptomic data of bovine ovarian granulosa cells of control and High A4 cows.

Alexandria P Snider, Sarah M Romereim, Renee M McFee, Adam F Summers, William E Pohlmeier, Scott G Kurz, John S Davis, Jennifer R Wood, Andrea S Cupp

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Alexandria P SniderAnimal Science, University of Nebraska-Lincoln, P.O. Box 830908, C203 ANSC, Lincoln, NE 68583-0908, USA.
Sarah M RomereimSchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, P.O. Box 830905, Lincoln, NE 68583-0905, USA.
Renee M McFeeSchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, P.O. Box 830905, Lincoln, NE 68583-0905, USA.
Adam F SummersAnimal and Range Sciences, New Mexico State University, Knox Hall Room 202; MSC 3-I Las Cruces, NM 88003, USA.
William E PohlmeierAnimal and Range Sciences, New Mexico State University, Knox Hall Room 202; MSC 3-I Las Cruces, NM 88003, USA.
Scott G KurzAnimal Science, University of Nebraska-Lincoln, P.O. Box 830908, C203 ANSC, Lincoln, NE 68583-0908, USA.
John S DavisOlson Center for Women's Health, University of Nebraska Medical Center, 983255 Nebraska Medical Center, Omaha, NE 68198-3255, USA.
Jennifer R WoodAnimal Science, University of Nebraska-Lincoln, P.O. Box 830908, C203 ANSC, Lincoln, NE 68583-0908, USA.
Andrea S CuppAnimal Science, University of Nebraska-Lincoln, P.O. Box 830908, C203 ANSC, Lincoln, NE 68583-0908, USA.
New Mexico State University · USUniversity of Nebraska–Lincoln · USUniversity of Nebraska Medical Center · USVA Nebraska Western Iowa Health Care System · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
UNMC Histology/Imaging and Creighton University Imaging Core FacilityP30GM110768 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WALSH, EDWARD J · 2014 to 2018
$5.1M
Metabolic Regulators of Corpus Luteum FunctionR01HD092263 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DAVIS, JOHN S · 2017 to 2021
$1.6M
Metabolic Events Controlling Ovarian SteroidogenesisR01HD087402 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DAVIS, JOHN S · 2017 to 2019
$425k
BLRD VA I01 BX004272BLRD VA IK6 BX005797NCI NIH HHS P30 CA036727NICHD NIH HHS R01 HD087402NICHD NIH HHS R01 HD092263NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P30 GM110768
6 · The paper itself

Abstract

Microarray analysis using Affymetrix Bovine GeneChip 1.0 ST Array to determine RNA expression analysis was performed on somatic granulosa cells from two different groups of cows classified based on androstenedione concentration within the follicular fluid (Control vs High A4) of estrogen-active dominant follicles. The normalized linear microarray data was deposited to the NCBI GEO repository (GSE97017 - RNA Expression Data from Bovine Ovarian Granulosa Cells from High or Low Androgen-Content Follicles). Subsequent ANOVA determined genes that were enriched (≥ 1.5 fold more) or decreased (≤ 1.5 fold less) in the High A4 granulosa cells compared to Control granulosa cells and analyzed filtered datasets of these differentially expressed genes are presented as tables. MicroRNAs that are differentially expressed in Control and High A4 granulosa cells are also reported in tables. The standard deviation of the analyzed array data in relation to the log of the expression values are shown as a figure. Ingenuity Pathway Analysis determined upstream regulators of differently expressed genes as presented in a table. These data have been further analyzed and interpreted in the companion article "A High-Androgen Microenvironment Inhibits Granulosa Cell Proliferation and Alters Cell Identity" (McFee et. al., 2021 [1].

Indexed as

BovineCell cycle arrestGranulosa cell microarrayHigh androgen microenvironmentmicroRNA

Identifiers

PMID34189206
PMCPMC8220326
OpenAlexW3168929434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.